Symptomatic acute Q fever: A series of 87 cases in an area of Mallorca

被引：6

作者：

Raya Cruz, Manuel ^{[1
]}

Gallego Lezaun, Cristina ^{[1
]}

Garcia Gasalla, Mercedes ^{[1
]}

Cifuentes Luna, Carmen ^{[1
]}

Forteza Forteza, Teodoro ^{[2
]}

Fernandez-Baca, Victoria ^{[2
]}

Gallegos Alvarez, Carmen ^{[2
]}

Payeras Cifre, Antonio ^{[1
]}

机构：

[1] Hosp Son Llatzer, Serv Med Interna & Enfermedades Infecciosas, Palma De Mallorca, Illes Balears, Spain

[2] Hosp Son Llatzer, Serv Microbiol Clin, Palma De Mallorca, Illes Balears, Spain

来源：

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2014年 / 32卷 / 04期

关键词：

Q fever; Prevalence; Pneumonia; Hepatitis; Treatment; Monitoring; COXIELLA-BURNETII; DIAGNOSIS; SEROPREVALENCE; GUIDELINES; MANAGEMENT; COMMUNITY; DISEASES;

D O I：

10.1016/j.eimc.2013.06.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Introduction: Q fever is a widespread zoonotic infection caused by Coxiella burnetii (C. burnetii). Acute infection varies from a self-limited flu-like illness to pneumonia or hepatitis. Methods: A retrospective case study from March 2003 to December 2011 was conducted in the Hospital Son Llatzer in Palma de Mallorca. Acute Q-fever was diagnosed in a patient with clinical suspicion and IgM in phase ii positive (>= 1/40), with a positive IgG (>= 1/80), or when IgG seroconversion was observed during convalescence. A total of 87 cases of acute Q fever were diagnosed. The median age was 50 years (range 21-89), and 69 (79.3%) were male. Fever and headache were the most common symptoms. Pneumonia was diagnosed in 39 (44.8%) patients, febrile episode in 21 (24.1%), and acute hepatitis in 23 (25.6%). Increased serum transaminases were observed in 19 (21.8%). Doxycycline was prescribed in 29 cases (33.4%). There were 30 (34.5%) patients lost to follow up after hospital discharge. A favorable outcome was observed in all other cases. Only one new case progressed to chronic Q fever. Results: A total of 87 cases of acute Q fever were diagnosed. The median age was 50 years (range 2189), and 69 (79.3%) were male. Fever and headache were the most common symptoms. Pneumonia was diagnosed in 39(44.8%) patients, febrile episode in 21 (24.1%), and acute hepatitis in 23 (25.6%). Increased serum transaminases were observed in 19(21.8%). Doxycycline was prescribed in 29 cases (33.4%). There were 30 (34.5%) patients lost to follow up after hospital discharge. A favorable outcome was observed in all other cases. Only one new case progressed to chronic Q fever. Conclusion: Acute Q fever acute is common our environment. Pneumonia was the most common clinical presentation. Even although doxycycline was prescribed in a small number of patients, a favorable outcome was observed in all cases. (C) 2013 Elsevier Espana, S.L. and Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. All rights reserved.

引用

页码：213 / 218

页数：6

共 32 条

[11] Defining chronic Q fever: A matter of debate [J].

Kampschreur, L. M. ;

Wever, P. C. ;

Wegdam-Blans, M. C. A. ;

Delsing, C. E. ;

Bleeker-Rovers, C. P. ;

Sprong, T. ;

van Kasteren, M. E. E. ;

Coutinho, R. A. ;

Schneeberger, P. M. ;

Notermans, D. W. ;

Bijlmer, H. A. ;

Koopmans, M. P. G. ;

Nabuurs-Franssen, M. H. ;

Oosterheert, J. J. .

JOURNAL OF INFECTION, 2012, 65 (04) :362-363

[12] Microbiological Challenges in the Diagnosis of Chronic Q Fever [J].

Kampschreur, Linda M. ;

Oosterheert, Jan Jelrik ;

Koop, Annemarie M. C. ;

Wegdam-Blans, Marjolijn C. A. ;

Delsing, Corine E. ;

Bleeker-Rovers, Chantal P. ;

De Jager-Leclercq, Monique G. L. ;

Groot, Cornelis A. R. ;

Sprong, Tom ;

Nabuurs-Franssen, Marrigje H. ;

Renders, Nicole H. M. ;

van Kasteren, Marjo E. ;

Soethoudt, Yvonne ;

Blank, Sybrandus N. ;

Pronk, Marjolijn J. H. ;

Groenwold, Rolf H. H. ;

Hoepelman, Andy I. M. ;

Wever, Peter C. .

CLINICAL AND VACCINE IMMUNOLOGY, 2012, 19 (05) :787-790

[13] Guidelines on the diagnosis and management of pericardial diseases -: Executive summary [J].

Maisch, B ;

Seferovic, PM ;

Ristic, AD ;

Erbel, R ;

Rienmüller, R ;

Adler, Y ;

Tomkowski, WZ ;

Thiene, G ;

Yacoub, MH .

EUROPEAN HEART JOURNAL, 2004, 25 (07) :587-610

[14] Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults [J].

Mandell, Lionel A. ;

Wunderink, Richard G. ;

Anzueto, Antonio ;

Bartlett, John G. ;

Campbell, G. Douglas ;

Dean, Nathan C. ;

Dowell, Scott F. ;

File, Thomas M., Jr. ;

Musher, Daniel M. ;

Niederman, Michael S. ;

Torres, Antonio ;

Whitney, Cynthia G. .

CLINICAL INFECTIOUS DISEASES, 2007, 44 :S27-S72

[15] SEROEPIDEMIOLOGY OF Q-FEVER IN NOVA-SCOTIA - EVIDENCE FOR AGE-DEPENDENT COHORTS AND GEOGRAPHICAL-DISTRIBUTION [J].

MARRIE, TJ ;

POLLAK, PT .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1995, 11 (01) :47-54

[16] Q fever [J].

Maurin, M ;

Raoult, D .

CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (04) :518-+

[17] Q fever: Current diagnosis and treatment options [J].

Million, M. ;

Lepidi, H. ;

Raoult, D. .

MEDECINE ET MALADIES INFECTIEUSES, 2009, 39 (02) :82-94

[18] Hemolytic anemia secondary to Q fever [J].

Muela Molinero, A. .

REVISTA CLINICA ESPANOLA, 2012, 212 (03) :162-163

[19] Outbreak of Q fever and seroprevalence in a rural town from Soria [J].

Nebreda, T ;

Contreras, E ;

Merino, FJ ;

Dodero, E ;

Campos, A .

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2001, 19 (02) :57-60

[20]

OGRADY JG, 1993, LANCET, V342, P273

← 1 2 3 4 →