Topical Application of Tranexamic Acid Plus Diluted Epinephrine Reduces Postoperative Hidden Blood Loss in Total Hip Arthroplasty

被引：26
作者：
Gao, Fuqiang [1 ]
Sun, Wei [1 ]
Guo, Wanshou [1 ]
Li, Zirong [1 ]
Wang, Weiguo [1 ]
Cheng, Liming [1 ]
机构：
[1] Natl Hlth & Family Planning Commiss Peoples Repub, Osteonecrosis & Joint Preserving & Reconstruct Ct, Dept Orthoped Surg, Beijing Key Lab Arthrit & Rheumat Dis,China Japan, Beijing, Peoples R China
来源：
JOURNAL OF ARTHROPLASTY | 2015年 / 30卷 / 12期
基金：
中国国家自然科学基金;
关键词：
topical; tranexamic acid; epinephrine; transfusion; hidden blood loss; total hip arthroplasty; TOTAL KNEE ARTHROPLASTY; RANDOMIZED CONTROLLED-TRIAL; TRANSFUSION RATES; REPLACEMENT; METAANALYSIS; MANAGEMENT; THROMBOPROPHYLAXIS; RIVAROXABAN; ENOXAPARIN; REDUCTION;
D O I：
10.1016/j.arth.2015.06.005
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
We evaluated the efficacy and safety of topical application of tranexamic acid (TXA) plus diluted epinephrine (DEP) and its effect on perioperative hidden blood loss and transfusion requirement in primary unilateral total hip arthroplasty (THA). We randomized 107 patients undergoing THA into two groups: 53 received intra-articular TXA 3 g plus 1: 200,000 DEP 0.25 mg; 54 received topical TXA 3 g alone. Results showed that combined administration significantly reduced total blood loss (P = 0.009), hidden blood loss (P = 0.001) and transfusion rate (1.9 vs. 9.3%) compared with TXA alone, without increasing the risks of thromboembolic and hemodynamic complications. Topical TXA plus DEP in THA can decrease postoperative hidden blood loss and avoid homologous transfusion without substantial complications. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：2196 / 2200
页数：5
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