Gastrointestinal Mucositis: The Role of MMP-Tight Junction Interactions in Tissue Injury

被引：18

作者：

Al-Dasooqi, Noor ^{[1
]}

Wardill, Hannah R. ^{[2
]}

Gibson, Rachel J. ^{[2
]}

机构：

[1] Univ Adelaide, Sch Med, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Sch Med Sci, Adelaide, SA 5005, Australia

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2014年 / 20卷 / 03期

关键词：

Matrix metalloproteinases; Tight junctions; Gut toxicity; Mucositis; Chemotherapy; ALIMENTARY-TRACT MUCOSITIS; BRAIN-BARRIER DISRUPTION; MATRIX METALLOPROTEINASES; INTESTINAL PERMEABILITY; CHEMOTHERAPY; MATRIX-METALLOPROTEINASE-9; APOPTOSIS; METALLOELASTASE; SUSCEPTIBILITY; INFLAMMATION;

D O I：

10.1007/s12253-013-9733-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase-dependent tight junction disruption may contribute to the pathobiology of mucositis.

引用

页码：485 / 491

页数：7

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