Encapsulation of Nutraceutical Ingredients in Liposomes and Their Potential for Cancer Treatment

被引:28
作者
Dutta, Sayantani [1 ]
Moses, Jeyan Arthur [1 ]
Anandharamakrishnan, C. [1 ]
机构
[1] Govt India, IIFPT, Minist Food Proc Ind, Computat Modeling & Nano Scale Proc Unit, Pudukkottai Rd, Thanjavur 613005, Tamil Nadu, India
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2018年 / 70卷 / 08期
关键词
BREAST-CANCER; IN-VITRO; MULTIDRUG-RESISTANCE; ANTICANCER ACTIVITY; P-GLYCOPROTEIN; DRUG-DELIVERY; KAPPA-B; CURCUMIN; MAGNETOLIPOSOMES; CELLS;
D O I
10.1080/01635581.2018.1557212
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
At present, cancer is one of the major diseases in the world affecting numerous lives. There have been various approaches to combat the disease, particularly involving chemical interventions (chemotherapy). However, owing to serious side effects of chemotherapy, employment of natural supplements in cancer therapy has been long desired. Nutraceuticals are currently being studied as a medicament, to act as both preventive and curative measure. Nutraceuticals provide both nutrition and therapeutic benefits; besides, they are natural and biocompatible, and therefore pose no side effects. This facilitates their ready acceptance as dietary supplements with no requirements of special dosage and concerns over long-term usage. Nutraceuticals can be derived from the natural resources such as spices, fruits, vegetables, and plants. However, nutraceuticals are vulnerable to environmental stresses that necessitate encapsulation for long-term storage and required bioavailability. The review collates the findings on encapsulated nutraceuticals in liposomes for cancer therapy. The article provides a coherent overview of the research conducted on liposomal administration of nutraceuticals to target various forms of cancer, explaining the advances made.
引用
收藏
页码:1184 / 1198
页数:15
相关论文
共 70 条
[1]   Synergistic radical scavenging potency of curcumin-in-β-cyclodextrin-in-nanomagnetoliposomes [J].
Aadinath, W. ;
Bhushani, Anu ;
Anandharamakrishnan, C. .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 64 :293-302
[2]   Liposomes - Opportunities in drug delivery [J].
Allen, TM .
DRUGS, 1997, 54 (Suppl 4) :8-14
[3]   Nanocarriers based delivery of nutraceuticals for cancer prevention and treatment: A review of recent research developments [J].
Arora, Divya ;
Jaglan, Sundeep .
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2016, 54 :114-126
[4]  
Aung H H, 2007, Exp Oncol, V29, P175
[5]  
Badawi AM, 2012, IMPORTANT FACTS CANC
[6]  
Cardoso BD, 2017, MAGNETOLIPOSOMES CON
[7]   Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells [J].
Catania, Angela ;
Barrajon-Catalan, Enrique ;
Nicolosi, Silvia ;
Cicirata, Federico ;
Micol, Vicente .
BREAST CANCER RESEARCH AND TREATMENT, 2013, 141 (01) :55-65
[8]   Nano-engineering of 5-fluorouracil-loaded magnetoliposomes for combined hyperthermia and chemotherapy against colon cancer [J].
Clares, Beatriz ;
Biedma-Ortiz, Rafael A. ;
Saez-Fernandez, Eva ;
Prados, Jose C. ;
Melguizo, Consolacion ;
Cabeza, Laura ;
Ortiz, Raul ;
Arias, Jose L. .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 85 (03) :329-338
[9]   PREPARATION AND CHARACTERIZATION OF NANO-BIO HYBRID BASED MAGNETO LIPOSOME [J].
Das, Amlan Kumar ;
Marwal, Avinash ;
Verma, Ruchi .
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2015, 6 (01) :367-375
[10]   Anticancer activities of (-)-epigallocatechin-3-gallate encapsulated nanoliposomes in MCF7 breast cancer cells [J].
de Pace, Rita Castillo Cohen ;
Liu, Xinli ;
Sun, Ming ;
Nie, Shufang ;
Zhang, Jia ;
Cai, Qingsong ;
Gao, Weimin ;
Pan, Xuan ;
Fan, Zhaoyang ;
Wang, Shu .
JOURNAL OF LIPOSOME RESEARCH, 2013, 23 (03) :187-196