Sympathetic Block with Botulinum Toxin to Treat Complex Regional Pain Syndrome

被引：86

作者：

Carroll, Ian ^{[1
]}

Clark, J. David ^{[2
]}

Mackey, Sean ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Anesthesiol, Stanford, CA 94304 USA

[2] Palo Alto Vet Affairs Hosp, Dept Anesthesiol, Palo Alto, CA USA

来源：

ANNALS OF NEUROLOGY | 2009年 / 65卷 / 03期

关键词：

RECEPTORS;

D O I：

10.1002/ana.21601

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Complex regional pain syndrome is a refractory pain condition with few tested therapies. We hypothesized that botulinum toxin A (BTA) would prolong analgesia after sympathetic blocks in patients with complex regional pain syndrome. We compared the duration of standard lumbar sympathetic block (LSB) with bupivacaine to LSB with bupivacaine and BTA in nine patients with refractory complex regional pain syndrome. Median time to analgesic failure was 71 (95% confidence interval, 12-253) days after LSB with BTA compared with fewer than 10 days (95% confidence interval, 0-12) after standard LSB (log-rank, p < 0.02). BTA profoundly prolonged the analgesia from sympathetic block in this preliminary study.

引用

页码：348 / 351

页数：4

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