Sympathetic Block with Botulinum Toxin to Treat Complex Regional Pain Syndrome

被引：84
作者：
Carroll, Ian [1 ]
Clark, J. David [2 ]
Mackey, Sean [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Anesthesiol, Stanford, CA 94304 USA
[2] Palo Alto Vet Affairs Hosp, Dept Anesthesiol, Palo Alto, CA USA
来源：
ANNALS OF NEUROLOGY | 2009年 / 65卷 / 03期
关键词：
RECEPTORS;
D O I：
10.1002/ana.21601
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Complex regional pain syndrome is a refractory pain condition with few tested therapies. We hypothesized that botulinum toxin A (BTA) would prolong analgesia after sympathetic blocks in patients with complex regional pain syndrome. We compared the duration of standard lumbar sympathetic block (LSB) with bupivacaine to LSB with bupivacaine and BTA in nine patients with refractory complex regional pain syndrome. Median time to analgesic failure was 71 (95% confidence interval, 12-253) days after LSB with BTA compared with fewer than 10 days (95% confidence interval, 0-12) after standard LSB (log-rank, p < 0.02). BTA profoundly prolonged the analgesia from sympathetic block in this preliminary study.
引用
收藏
页码：348 / 351
页数：4
相关论文
共 19 条
  • [1] Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain
    Ali, Z
    Raja, SN
    Wesselmann, U
    Fuchs, PN
    Meyer, RA
    Campbell, JN
    [J]. PAIN, 2000, 88 (02) : 161 - 168
  • [2] A focused review on the use of botulinum toxins for neuropathic pain
    Argoff, CE
    [J]. CLINICAL JOURNAL OF PAIN, 2002, 18 (06) : S177 - S181
  • [3] Expression of α2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation
    Birder, LA
    Perl, ER
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1999, 515 (02): : 533 - 542
  • [4] Effect of adrenergic receptor activation on post-herpetic neuralgia pain and sensory disturbances
    Choi, B
    Rowbotham, MC
    [J]. PAIN, 1997, 69 (1-2) : 55 - 63
  • [5] Datta Sukdeb, 2004, Pain Physician, V7, P53
  • [6] The incidence of complex regional pain syndrome: A population-based study
    de Mos, M.
    de Bruijn, A. G. J.
    Huygen, F. J. P. M.
    Dieleman, J. P.
    Stricker, B. H. Ch.
    Sturkenboom, M. C. J. M.
    [J]. PAIN, 2007, 129 (1-2) : 12 - 20
  • [7] Effects of botulinum toxin type A on the superior cervical ganglia in rabbits
    Kim, HJ
    Seo, K
    Yum, KW
    Oh, YS
    Yoon, TG
    Yoon, SM
    [J]. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2002, 102 (1-2): : 8 - 12
  • [8] Mailis A., 2003, COCHRANE DB SYST REV, pCD002918, DOI DOI 10.1002/14651858.CD002918
  • [9] Management of lower limb complex regional pain syndrome type 1: An evaluation of percutaneous Radiofrequency thermal lumbar sympathectomy versus phenol lumbar sympathetic neurolysis - A pilot study
    Manjunath, Prashanth S.
    Jayalakshmi, T. S.
    Dureja, G. P.
    Prevost, A. Toby
    [J]. ANESTHESIA AND ANALGESIA, 2008, 106 (02) : 647 - 649
  • [10] [Merskey H. IASP. IASP.], 1994, IASP Task Force on Taxonomy, VSecond
12