Bi-directional activation of inflammation and coagulation in septic neonates

被引：6
作者：
Del Vecchio, Antonio [1 ]
Stronati, Mauro [2 ]
Franco, Caterina [1 ]
Christensen, Robert D. [3 ]
机构：
[1] Di Venere Hosp, Div Neonatol, Neonatal Intens Care Unit, I-70121 Bari, Italy
[2] Fdn IRCCS Policlin San Matteo, Maternal Infant Dept, Neonatal Intens Care Unit, Pavia, Italy
[3] Intermt Healthcare, Women & Newborns Program, Salt Lake City, UT USA
来源：
EARLY HUMAN DEVELOPMENT | 2014年 / 90卷
关键词：
Neonate; Sepsis; Coagulation; Inflammatory cytokines; Inflammation; PROTEIN-C; HEMOSTASIS; SYSTEM; SEPSIS; TERM;
D O I：
10.1016/S0378-3782(14)70008-8
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Neonatal sepsis is frequently accompaniedby significant and sometimes life-threatening coagulopathy. More complete understanding is needed of the molecular and cellular mechanisms underlying the interaction of the inflammatory and hemostatic systems. Such information may help focus future studies toward novel ways to improve the outcome of neonates who develop septic coagulopathy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：S22 / S25
页数：4
相关论文
共 23 条
  • [1] ANDREW M, 1988, BLOOD, V72, P1651
  • [2] DEVELOPMENT OF THE HUMAN COAGULATION SYSTEM IN THE FULL-TERM INFANT
    ANDREW, M
    PAES, B
    MILNER, R
    JOHNSTON, M
    MITCHELL, L
    TOLLEFSEN, DM
    POWERS, P
    [J]. BLOOD, 1987, 70 (01) : 165 - 172
  • [3] The relevance of developmental hemostasis to hemorrhagic disorders of newborns
    Andrew, M
    [J]. SEMINARS IN PERINATOLOGY, 1997, 21 (01) : 70 - 85
  • [4] Armstrong-Wells JL, 2012, NEONATOLOGY PRACTICA, P770
  • [5] Reference intervals for common coagulation tests of preterm infants
    Christensen, Robert D.
    Baer, Vickie L.
    Lambert, Diane K.
    Henry, Erick
    Ilstrup, Sarah J.
    Bennett, Sterling T.
    [J]. TRANSFUSION, 2014, 54 (03) : 627 - 632
  • [6] The role of molecular genetics in the pathogenesis and diagnosis of neonatal sepsis
    Del Vecchio, A
    Laforgia, N
    Capasso, M
    Iolascon, A
    Latini, G
    [J]. CLINICS IN PERINATOLOGY, 2004, 31 (01) : 53 - +
  • [7] Edstrom CS, 2000, HEMATOLOGIC PROBLEMS, P247
  • [8] New insights into thrombopoiesis in neonatal sepsis
    Eissa, Deena S.
    El-Farrash, Rania A.
    [J]. PLATELETS, 2013, 24 (02) : 122 - 128
  • [9] Study of protein C, protein S, and antithrombin III in newborns with sepsis
    El Beshlawy, Amal
    Alaraby, Ibrahim
    Abou Hussein, Heba
    Abou-Elew, Heba Hassan
    Kader, Mohamed Salah Eldin Mohamed Abdel
    [J]. PEDIATRIC CRITICAL CARE MEDICINE, 2010, 11 (01) : 52 - 59
  • [10] Severe sepsis, coagulation, and fibrinolysis: Dead end or one way?
    Fourrier, Francois
    [J]. CRITICAL CARE MEDICINE, 2012, 40 (09) : 2704 - 2708
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