A review of the MHC genetics of rheumatoid arthritis

被引：175
作者：
Newton, JL [1 ]
Harney, SMJ [1 ]
Wordsworth, BP [1 ]
Brown, MA [1 ]
机构：
[1] Univ Oxford, Botnar Res Ctr, Nuffield Orthopaed Ctr, Inst Musculoskeletal Sci, Oxford, England
来源：
GENES AND IMMUNITY | 2004年 / 5卷 / 03期
关键词：
major histocompatibility complex; rheumatoid arthritis; genetics;
D O I：
10.1038/sj.gene.6364045
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.
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收藏
页码：151 / 157
页数：7
相关论文
共 87 条
  • [1] AHO K, 1986, J RHEUMATOL, V13, P899
  • [2] ANALYSIS OF HLA DP, DQ, AND DR ALLELES IN ADULT ITALIAN RHEUMATOID-ARTHRITIS PATIENTS
    ANGELINI, G
    MOROZZI, G
    DELFINO, L
    PERA, C
    FALCO, M
    MARCOLONGO, R
    GIANNELLI, S
    RATTI, G
    RICCI, S
    FANETTI, G
    FERRARA, GB
    [J]. HUMAN IMMUNOLOGY, 1992, 34 (02) : 135 - 141
  • [3] Genetic analysis of multiplex rheumatoid arthritis families
    Bali, D
    Gourley, S
    Kostyu, DD
    Goel, N
    Bruce, I
    Bell, A
    Walker, DJ
    Tran, K
    Zhu, DK
    Costello, TJ
    Amos, CI
    Seldin, MF
    [J]. GENES AND IMMUNITY, 1999, 1 (01) : 28 - 36
  • [4] Barrera P, 2000, ARTHRITIS RHEUM, V43, P758, DOI 10.1002/1529-0131(200004)43:4<758::AID-ANR6>3.0.CO
  • [5] 2-6
  • [6] Barrera P, 2001, J RHEUMATOL, V28, P968
  • [7] HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice - Implications in human rheumatoid arthritis
    Bradley, DS
    Nabozny, GH
    Cheng, S
    Zhou, P
    Griffiths, MM
    Luthra, HS
    David, CS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (09) : 2227 - 2234
  • [8] Brinkman BMN, 1997, BRIT J RHEUMATOL, V36, P516
  • [9] TUMOR-NECROSIS-FACTOR ALPHA-308 GENE VARIANTS IN RELATION TO MAJOR HISTOCOMPATIBILITY COMPLEX ALLELES AND FELTYS-SYNDROME
    BRINKMAN, BMN
    GIPHART, MJ
    VERHOEF, A
    KAIJZEL, EL
    NAIPAL, AMIH
    DAHA, MR
    BREEDVELD, FC
    VERWEIJ, CL
    [J]. HUMAN IMMUNOLOGY, 1994, 41 (04) : 259 - 266
  • [10] Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1*alleles in Peruvian patients with rheumatoid arthritis
    Castro, F
    Acevedo, E
    Ciusani, E
    Angulo, JA
    Wollheim, FA
    Sandberg-Wollheim, M
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (08) : 791 - 795
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