Therapeutic potential of sulfur-containing natural products in inflammatory diseases

被引:42
作者
Cao, Xu [2 ]
Cao, Lei [2 ]
Zhang, Wencan [3 ]
Lu, Rongzhu [4 ]
Bian, Jin-Song [1 ,2 ]
Nie, Xiaowei [2 ,5 ]
机构
[1] Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore
[3] Natl Univ Singapore, Dept Chem, Food Sci & Technol Program, Singapore 117600, Singapore
[4] Jiangsu Univ, Sch Med, Dept Prevent Med & Publ Hlth Lab Sci, Zhenjiang 212013, Jiangsu, Peoples R China
[5] Southern Univ Sci & Technol, Affiliated Hosp 2, Inst Hepatol, Shenzhen 518055, Peoples R China
关键词
Inflammation; Garlic-derived compounds; Epipolythiodioxopiperazines; Isothiocyanates; Ergothioneine; Hydrogen sulfide; FACTOR-KAPPA-B; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GARLIC ORGANOSULFUR COMPOUNDS; MOUSE PERITONEAL-MACROPHAGES; ENDOGENOUS HYDROGEN-SULFIDE; LPS-INDUCED INFLAMMATION; NLRP3; INFLAMMASOME; IN-VITRO; N-ACETYLCYSTEINE; HEME OXYGENASE-1;
D O I
10.1016/j.pharmthera.2020.107687
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Owing to the prevalence of chronic inflammation and its related disorders, there is a demand for novel therapeutic agents capable of preventing or suppressing inflammation. Natural products (NPs) are well established as an important resource for drug development and provide an almost infinite array of molecular entities. Sulfur containing NPs (i.e., NPs containing one or more sulfur atoms) are abundant throughout nature, from bacteria to animals. The aim of this review was to survey the emerging evidence on role of sulfur-containing NPs, such as glutathione, garlic-derived sulfur compounds, Epipolythiodioxopiperazines (EPTs), Isothiocyanates (ITCs), and Ergothioneine (EGT), in the control of inflammation and to determine the possible underlying mechanisms. A discussion of how hydrogen sulfide (H2S), an endogenous gaseous signaling molecule, links sulfur-containing NPs and their anti-inflammatory action is also performed. This review may help to further the development of sulfur-based compounds by providing a guide for structure-activity relationship-based modification for use in modern medicinal chemistry. However, as this field is still in its infancy, the review is concluded by an overview of the progression of these promising entities as therapeutic agents. (C) 2020 Elsevier Inc. All rights reserved.
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页数:13
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共 168 条
[1]   Controlled trial of N-acetyleysteine for patients with probable Alzheimer's disease [J].
Adair, JC ;
Knoefel, JE ;
Morgan, N .
NEUROLOGY, 2001, 57 (08) :1515-1517
[2]  
Adcock I M, 1997, Monaldi Arch Chest Dis, V52, P178
[3]   An epigenetic silencing pathway controlling T helper 2 cell lineage commitment [J].
Allan, Rhys S. ;
Zueva, Elina ;
Cammas, Florence ;
Schreiber, Heidi A. ;
Masson, Vanessa ;
Belz, Gabrielle T. ;
Roche, Daniele ;
Maison, Christele ;
Quivy, Jean-Pierre ;
Almouzni, Genevieve ;
Amigorena, Sebastian .
NATURE, 2012, 487 (7406) :249-U137
[4]   TLRs in pulmonary diseases [J].
Arora, Shweta ;
Ahmad, Shaniya ;
Irshad, Rasha ;
Goyal, Yamini ;
Rafat, Sahar ;
Siddiqui, Neha ;
Dev, Kapil ;
Husain, Mohammad ;
Ali, Shakir ;
Mohan, Anant ;
Syed, Mansoor Ali .
LIFE SCIENCES, 2019, 233
[5]   A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation [J].
Asahi, Takashi ;
Wu, Xiaohong ;
Shimoda, Hiroshi ;
Hisaka, Shinsuke ;
Harada, Etsuko ;
Kanno, Tomomi ;
Nakamura, Yoshimasa ;
Kato, Yoji ;
Osawa, Toshihiko .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2016, 80 (02) :313-317
[6]  
Bacchi S., 2012, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, V11, P52
[7]   Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities [J].
Back, Magnus ;
Yurdagul, Arif, Jr. ;
Tabas, Ira ;
Oorni, Katariina ;
Kovanen, Petri T. .
NATURE REVIEWS CARDIOLOGY, 2019, 16 (07) :389-406
[8]   Anti-inflammatory and arthritic effects of thiacremonone, a novel sulfurcompound isolated from garlic via inhibition of NF-κB [J].
Ban, Jung Ok ;
Oh, Ju Hoon ;
Kim, Tae Myoung ;
Kim, Dae Joong ;
Jeong, Heon-Sang ;
Han, Sang Bae ;
Hong, Jin Tae .
ARTHRITIS RESEARCH & THERAPY, 2009, 11 (05)
[9]   Cellular and molecular mechanisms of asthma and COPD [J].
Barnes, Peter J. .
CLINICAL SCIENCE, 2017, 131 (13) :1541-1558
[10]   NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223 [J].
Bauernfeind, Franz ;
Rieger, Anna ;
Schildberg, Frank A. ;
Knolle, Percy A. ;
Schmid-Burgk, Jonathan L. ;
Hornung, Veit .
JOURNAL OF IMMUNOLOGY, 2012, 189 (08) :4175-4181