Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy

被引：41
作者：
Chen, Junjie [1 ]
Pan, Hua [1 ]
Lanza, Gregory M. [1 ]
Wickline, Samuel A. [1 ]
机构：
[1] Washington Univ, Dept Med, St Louis, MO 63108 USA
来源：
ADVANCES IN CHRONIC KIDNEY DISEASE | 2013年 / 20卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Nanoparticles; Molecular imaging; Perfluorocarbon; Perfusion; Oxygenation; F-19; MAGNETIC-RESONANCE; NEAR-INFRARED SPECTROSCOPY; TARGETED FUMAGILLIN NANOPARTICLES; TISSUE FACTOR EXPRESSION; TUMOR OXYGEN DYNAMICS; SMOOTH-MUSCLE-CELLS; VX-2 RABBIT TUMORS; IN-VIVO; CONTRAST AGENT; BLOOD-FLOW;
D O I：
10.1053/j.ackd.2013.08.004
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Herein, we review the use of non-nephrotoxic perfluorocarbon nanoparticles (PFC NPs) for noninvasive detection and therapy of kidney diseases, and we provide a synopsis of other related literature pertinent to their anticipated clinical application. Recent reports indicate that PFC NPs allow for quantitative mapping of kidney perfusion and oxygenation after ischemia-reperfusion injury with the use of a novel multinuclear H-1/F-19 magnetic resonance imaging approach. Furthermore, when conjugated with targeting ligands, the functionalized PFC NPs offer unique and quantitative capabilities for imaging inflammation in the kidney of atherosclerotic ApoE-null mice. In addition, PFC NPs can facilitate drug delivery for treatment of inflammation, thrombosis, and angiogenesis in selected conditions that are comorbidities for kidney failure. The excellent safety profile of PFC NPs with respect to kidney injury positions these nanomedicine approaches as promising diagnostic and therapeutic candidates for treating and following acute and chronic kidney diseases. (C) 2013 by the National Kidney Foundation, Inc. All rights reserved.
引用
收藏
页码：466 / 478
页数：13
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