Acorus tatarinowii Schott extract protects PC12 cells from amyloid-β induced neurotoxicity

被引：18
|
作者：
An, Hong-Mei [1 ]
Li, Guo-Wen [2 ]
Lin, Chen [1 ]
Gu, Chao [1 ]
Jin, Miao [1 ]
Sun, Wen-Xian [1 ]
Qiu, Ming-Feng [3 ]
Hu, Bing [4 ,5 ]
机构：
[1] Longhua Hosp, Dept Neurol, Shanghai, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Oncol, Shanghai, Peoples R China
[5] Shanghai Univ Tradit Chinese Med, Inst Tradit Chinese Med Oncol, Shanghai, Peoples R China
来源：
PHARMAZIE | 2014年 / 69卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ALZHEIMERS-DISEASE; OXIDATIVE STRESS; DEATH; ANTIOXIDANT; DAMAGE;
D O I：
10.1691/ph.2014.3662
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Amyloid-beta induced neurotoxicity has been identified as a major cause of Alzheimer's disease. Acorus tatarinowii Schott is one of the most frequently used Chinese herbs for Alzheimer's disease treatment. However, the effects of Acorus tatarinowii Schott on amyloid-beta mediated nerve cell damage remains unknown. In the present study, neuronal differentiated PC12 cells were used as a model to evaluate the effects of A. tatarinowii Schott extract (ATSE) against A beta(25-35) induced neurotoxicity. The results showed pretreatment with ATSE significantly protected PC12 cells from A beta(25-35) induced cell death, lactate dehydrogenase release, DNA damage, mitochondrial dysfunction and cytochrome c release from mitochondria. In addition, pretreatment with ATSE also significantly inhibited A beta(25-35) induced caspase-3 activation and reactive oxygen species generation in PC12 cells. These observations suggested that ATSE protects PC12 cells from amyloid-p induced neurotoxicity.
引用
收藏
页码：391 / 395
页数：5
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