Dairy-derived antimicrobial peptides: Action mechanisms, pharmaceutical uses and production proposals

被引：77

作者：

Akalin, A. Sibel ^{[1
]}

机构：

[1] Ege Univ, Fac Agr, Dept Dairy Technol, TR-35100 Izmir, Turkey

来源：

TRENDS IN FOOD SCIENCE & TECHNOLOGY | 2014年 / 36卷 / 02期

关键词：

ENTEROPATHOGENIC ESCHERICHIA-COLI; WATER-SOLUBLE EXTRACTS; BIOACTIVE PEPTIDES; ALPHA-LACTALBUMIN; HUMAN-MILK; ANTIBACTERIAL PEPTIDES; BOVINE-MILK; LISTERIA-MONOCYTOGENES; BETA-LACTOGLOBULIN; WHEY-PROTEIN;

D O I：

10.1016/j.tifs.2014.01.002

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Milk proteins are precursors of many different biologically active peptides including antimicrobial ones. These peptides have already been considered for application both as dietary supplements in "functional foods" and as drugs. This review focuses on the recent knowledge pertaining to antimicrobial peptides derived from major milk proteins (caseins and whey proteins) and the mechanism of action of these peptides. Possible applications in the pharmaceutical industry and processing technologies designed for the large-scale production of these protein fragments are also discussed.

引用

页码：79 / 95

页数：17

共 107 条

[1] Rethinking food-derived bioactive peptides for antimicrobial and immunomodulatory activities [J].

Agyei, Dominic ;

Danquah, Michael K. .

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2012, 23 (02) :62-69

[2] Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides [J].

Agyei, Dominic ;

Danquah, Michael K. .

BIOTECHNOLOGY ADVANCES, 2011, 29 (03) :272-277

[3] Degradation of whey from caprine milk by human proteolytic enzymes, and the resulting antibacterial effect against Listeria monocytogenes [J].

Almaas, H. ;

Berner, V. ;

Holm, H. ;

Langsrud, T. ;

Vegarud, G. E. .

SMALL RUMINANT RESEARCH, 2008, 79 (01) :11-15

[4] In vitro studies of the digestion of caprine whey proteins by human gastric and duodenal juice and the effects on selected microorganisms [J].

Almaas, Hilde ;

Holm, Halvor ;

Langsrud, Thor ;

Flengsrud, Ragnar ;

Vegarud, Gerd E. .

BRITISH JOURNAL OF NUTRITION, 2006, 96 (03) :562-569

[5] Structure-Activity Relationship of Synthetic Variants of the Milk-Derived Antimicrobial Peptide αs2-Casein f(183-207) [J].

Alvarez-Ordonez, Avelino ;

Begley, Maire ;

Clifford, Tanya ;

Deasy, Therese ;

Considine, Kiera ;

Hill, Colin .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2013, 79 (17) :5179-5185

[6] New peptides obtained by hydrolysis of caseins from bovine milk by protease extracted from the latex Jacaratia corumbensis [J].

Arruda, M. S. ;

Silva, F. O. ;

Egito, A. S. ;

Silva, T. M. S. ;

Lima-Filho, J. L. ;

Porto, A. L. F. ;

Moreira, K. A. .

LWT-FOOD SCIENCE AND TECHNOLOGY, 2012, 49 (01) :73-79

[7] The development of electro-membrane filtration for the isolation of bioactive peptides: the effect of membrane selection and operating parameters on the transport rate [J].

Bargeman, G ;

Koops, GH ;

Houwing, J ;

Breebaart, I ;

van der Horst, HC ;

Wessling, M .

DESALINATION, 2002, 149 (1-3) :369-374

[8] Antimicrobial peptides generated from milk proteins: a survey and prospects for application in the food industry. A review [J].

Benkerroum, Noreddine .

INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, 2010, 63 (03) :320-338

[9] Hierarchical mesoporous silica materials for separation of functional food ingredients - A review [J].

Brady, Ryan ;

Woonton, Brad ;

Gee, Michelle L. ;

O'Connor, Andrea J. .

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES, 2008, 9 (02) :243-248

[10] The effects of α-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri [J].

Bruck, WM ;

Kelleher, SL ;

Gibson, GR ;

Graverholt, G ;

Lonnerdal, BL .

FEMS MICROBIOLOGY LETTERS, 2006, 259 (01) :158-162

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