Improvements in aldol reactions with diketopiperazines

被引：18
作者：
González, JF [1 ]
de la Cuesta, E [1 ]
Avendaño, C [1 ]
机构：
[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain
来源：
SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 09期
关键词：
aldol reaction; diketopiperazines; ortho-directed lithiation;
D O I：
10.1081/SCC-120030746
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Precipitation of products by using dichloromethane as solvent permits an efficient aldol-type reaction between 1,4-diacetyl-2,5-piperazinedione and aromatic aldehydes catalyzed by K'BuO/'BuOH independently of the electrophilic character of the aryl ring. A simple method to obtain 3-methyl-2,4,5-trimethoxybenzaldehyde is also reported.
引用
收藏
页码：1589 / 1597
页数：9
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