Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Alkyl Grignard Reagents and Identification of Selective Anti-Breast-Cancer Agents

被引：126

作者：

Yonova, Ivelina M. ^{[1
]}

Johnson, A. George ^{[1
]}

Osborne, Charlotte A. ^{[1
]}

Moore, Curtis E. ^{[3
]}

Morrissette, Naomi S. ^{[2
]}

Jarvo, Elizabeth R. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 09期

关键词：

alkyl Grignard reagents; breast cancer; enantiospecificity; Kumada coupling; nickel; ENANTIOSELECTIVE ADDITION; STEREOSELECTIVE-SYNTHESIS; BORONIC ACIDS; ALDEHYDES; ESTERS; CONSTRUCTION; SUBSTITUTION; RETENTION; COMPLEXES; LIGAND;

D O I：

10.1002/anie.201308666

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alkyl Grignard reagents that contain beta-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.

引用

页码：2422 / 2427

页数：6

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