The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies: Independent and Interdependent Biomarkers of Disease

被引:23
作者
Mehra, Sonal [1 ]
Fritzler, Marvin J. [2 ]
机构
[1] JIPMER, Dept Clin Immunol, Pondicherry 605006, India
[2] Univ Calgary, Fac Med, Calgary, AB T2N 4N1, Canada
关键词
SYSTEMIC-LUPUS-ERYTHEMATOSUS; NEUTROPHIL EXTRACELLULAR TRAPS; DOUBLE-STRANDED DNA; NONHISTONE CHROMOSOMAL-PROTEINS; NUCLEOSOME-RESTRICTED ANTIBODIES; MOBILITY GROUP PROTEINS; ANTINUCLEOSOME ANTIBODIES; CHROMATIN ANTIBODIES; DSDNA ANTIBODIES; ANTIHISTONE ANTIBODIES;
D O I
10.1155/2014/368274
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Autoantibodies directed to chromatin components date back to the discovery of the LE cell and the LE cell phenomenon circa 1950, and subsequent evidence that major components of that reaction were chromatin components and histones in particular. Over time, immunoassays ranging from ELISA and line immunoassays to more modern bead-based assays incorporated histone and DNA mixtures, purified histones, and purified nucleosomes leading to a more thorough understanding of the genesis and pathogenetic relationships of antibodies to chromatin components in systemic lupus erythematosus and other autoimmune conditions. More recently, interest has focussed on other components of chromatin such as high mobility group (HMG) proteins both as targets of B cell responses and pro-inflammatory mediators. This review will focus on immunoassays that utilize chromatin components, their clinical relationships, and newer evidence implicating HMG proteins and DNA neutrophil extracellular traps (NETs) as important players in systemic autoimmune rheumatic diseases.
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页数:15
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