Antibacterial activity of gemini quaternary ammonium salts

被引：51

作者：

Oblak, Ewa ^{[1
]}

Piecuch, Agata ^{[1
]}

Guz-Regner, Katarzyna ^{[1
]}

Dworniczek, Ewa ^{[2
]}

机构：

[1] Univ Wroclaw, Inst Genet & Microbiol, PL-51148 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Microbiol, Wroclaw, Poland

来源：

FEMS MICROBIOLOGY LETTERS | 2014年 / 350卷 / 02期

关键词：

gemini quaternary ammonium salts; cationic surfactants; biofilm; adhesion; PSEUDOMONAS-AERUGINOSA; BIOFILM FORMATION; STAPHYLOCOCCUS-EPIDERMIDIS; BACTERIAL ADHESION; SURFACTANTS; RESISTANCE;

D O I：

10.1111/1574-6968.12331

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A series of gemini quaternary ammonium salts (chlorides and bromides), with various hydrocarbon chain and spacer lengths, were tested. These compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria and were not mutagenic. The strongest antibacterial effect was observed for TMPG-10 Cl (against Pseudomonas aeruginosa ATCC 27853) and TMPG-12 Br (against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 11229 and clinical ESBL(+) isolate 434) surfactants. These compounds inhibited the adhesion of Staphylococcus epidermidis ATCC 35984 to a polystyrene surface and eradicated biofilm formed by P.aeruginosa PAO1. The activity of studied compounds was dependent on hydrocarbon chain length.

引用

页码：190 / 198

页数：9

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