Antibacterial activity of gemini quaternary ammonium salts

被引：51
|
作者：
Oblak, Ewa [1 ]
Piecuch, Agata [1 ]
Guz-Regner, Katarzyna [1 ]
Dworniczek, Ewa [2 ]
机构：
[1] Univ Wroclaw, Inst Genet & Microbiol, PL-51148 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Microbiol, Wroclaw, Poland
来源：
FEMS MICROBIOLOGY LETTERS | 2014年 / 350卷 / 02期
关键词：
gemini quaternary ammonium salts; cationic surfactants; biofilm; adhesion; PSEUDOMONAS-AERUGINOSA; BIOFILM FORMATION; STAPHYLOCOCCUS-EPIDERMIDIS; BACTERIAL ADHESION; SURFACTANTS; RESISTANCE;
D O I：
10.1111/1574-6968.12331
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A series of gemini quaternary ammonium salts (chlorides and bromides), with various hydrocarbon chain and spacer lengths, were tested. These compounds exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria and were not mutagenic. The strongest antibacterial effect was observed for TMPG-10 Cl (against Pseudomonas aeruginosa ATCC 27853) and TMPG-12 Br (against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 11229 and clinical ESBL(+) isolate 434) surfactants. These compounds inhibited the adhesion of Staphylococcus epidermidis ATCC 35984 to a polystyrene surface and eradicated biofilm formed by P.aeruginosa PAO1. The activity of studied compounds was dependent on hydrocarbon chain length.
引用
收藏
页码：190 / 198
页数：9
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