Endostatin's endpoints-deciphering the endostatin antiangiogenic pathway

被引：32

作者：

Benezra, R

Rafii, S

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Cornell Univ, Coll Med, Dept Med Genet, New York, NY 10021 USA

来源：

CANCER CELL | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1535-6108(04)00057-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Up until now, the precise mechanism for endostatin's antiangiogenesis action was not known. In a recent report, Abdollahi et al. (2004) have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect the molecular pathways involved in endostatin's selective tumor antiangiogenic effects.

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页码：205 / 206

页数：2

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