Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

被引：32

作者：

Malatinkova, Eva ^{[1
,2
]}

De Spiegelaere, Ward ^{[1
,2
]}

Bonczkowski, Pawel ^{[1
,2
]}

Kiselinova, Maja ^{[1
,2
]}

Vervisch, Karen ^{[1
,2
]}

Trypsteen, Wim ^{[1
,2
]}

Johnson, Margaret ^{[3
]}

Verhofstede, Chris ^{[4
]}

de Looze, Danny ^{[5
]}

Murray, Charles ^{[6
]}

Kiloch-de Loes, Sabine ^{[3
]}

Vandekerckhove, Linos ^{[1
,2
]}

机构：

[1] Univ Ghent, HIV Translat Res Unit, Dept Internal Med, Fac Med & Hlth Sci, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Ghent, Belgium

[3] Royal Free Hosp, Div Infect & Immun, London NW3 2QG, England

[4] Univ Ghent, AIDS Reference Lab, Dept Clin Chem Microbiol & Immunol, B-9000 Ghent, Belgium

[5] Ghent Univ Hosp, Dept Gastroenterol, Ghent, Belgium

[6] Royal Free Hosp, Dept Gastroenterol, London NW3 2QG, England

来源：

ELIFE | 2015年 / 4卷

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; TERMINAL REPEAT CIRCLES; CD4(+) T-CELLS; VIRAL PERSISTENCE; IMMUNE ACTIVATION; INFECTED PATIENTS; DNA; REPLICATION; INTEGRATION; LATENT;

D O I：

10.7554/eLife.09115

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-naive seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.

引用

页数：17

共 70 条

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