Synthesis, photophysical and antioxidant properties of carbazole-based bis-thiosemicarbazones

被引：23

作者：

Bingul, Murat ^{[1
]}

Senkuytu, Elif ^{[2
]}

Saglam, Mehmet F. ^{[2
]}

Boga, Mehmet ^{[3
]}

Kandemir, Hakan ^{[4
]}

Sengul, Ibrahim F. ^{[2
]}

机构：

[1] Dicle Univ, Fac Pharm, Dept Pharmaceut Chem, TR-21280 Diyarbakir, Turkey

[2] Gebze Tech Univ, Dept Chem, Fac Sci, Kocaeli, Turkey

[3] Dicle Univ, Dept Pharmaceut Technol, Fac Pharm, TR-21280 Diyarbakir, Turkey

[4] Namik Kemal Univ, Fac Art & Sci, Dept Chem, Tekirdag, Turkey

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2019年 / 45卷 / 09期

关键词：

Carbazole; Thiosemicarbazone; Antioxidant activities; Photophysical properties; LIGAND SYNTHESIS; FLUORESCENCE; DERIVATIVES; COPPER(II); COMPLEXES; IRON;

D O I：

10.1007/s11164-019-03844-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Utilizing Schiff base condensation of the 9-ethylcarbazole-3,6-dicarbaldehyde and thiosemicarbazides, four new N-ethylcarbazole-based bis-thiosemicarbazone compounds 4a-d were successfully synthesized in high yields. The photophysical properties of the targeted compounds 4a-d were investigated using UV-vis absorption and fluorescence emission spectroscopy. The antioxidant properties of targeted compounds 4a-d were determined by DPPH radical scavenging, ABTS Cation Radical Decolarization and CUPRAC Cupric Reducing Antioxidant Capacity assay methods. Moreover, the anti-cholinesterase properties of designated compounds were investigated by the Acetylcholinesterase (Ach) and Butyrylcholinesterase (BCh) enzyme inhibition assays. The compound 4a was determined as a valuable candidate to be a potent antioxidant agent for the DPPH and ABTS assays. The compound 4d was found to be a target compound for the kinetic measurements to identify the mechanism of action in the area of anticholinesterase activity assay.

引用

页码：4487 / 4499

页数：13

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