Pathogenesis of atopic dermatitis: New developments

被引：48

作者：

Bieber, Thomas ^{[1
]}

Novak, Natalija ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, D-53105 Bonn, Germany

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2009年 / 9卷 / 04期

关键词：

TOLL-LIKE RECEPTOR-2; OF-FUNCTION MUTATIONS; FILAGGRIN GENE; ANTIMICROBIAL PEPTIDES; CONTACT-DERMATITIS; R753Q POLYMORPHISM; SKIN INFLAMMATION; STRATUM-CORNEUM; BETA-DEFENSINS; MAST-CELLS;

D O I：

10.1007/s11882-009-0041-2

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a paradigmatic skin disease in which multiple gene-gene and gene-environment interactions play a pivotal role. Although the complex pathophysiologic network of AD explains the large spectrum of risk and trigger factors, it is far from being comprehensively understood. Hence, genetic modifications underlying the dysfunction of the epidermal skin barrier as well as the close interaction of innate and adaptive immune mechanisms were the focus of intensive research studies. This review aims to summarize the most recent findings in this field.

引用

页码：291 / 294

页数：4

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