Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material

被引：89
作者：
Bogdanski, D
Köller, M
Müller, D
Muhr, G
Bram, M
Buchkremer, HP
Stöver, D
Choi, J
Epple, M
机构：
[1] Ruhr Univ Bochum, Fac Chem Solid State Chem, D-44780 Bochum, Germany
[2] Forschungszentrum Julich, Inst Mat & Proc Energy Syst, IWV 1, D-52425 Julich, Germany
[3] Ruhr Univ Bochum, Dept Surg, BG Kliniken Bergmannsheil, D-44780 Bochum, Germany
来源：
BIOMATERIALS | 2002年 / 23卷 / 23期
关键词：
Ni-Ti shape memory alloys; biocompatibility; metallic implants; nickel alloys; titanium alloys;
D O I：
10.1016/S0142-9612(02)00200-4
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The biocompatibility of nickel-titanium alloys was investigated by single-culture experiments on functionally graded samples with a stepwise change in composition from pure nickel to pure titanium, including an Ni-Ti shape memory alloy for a 50:50 mixture. This approach permitted a considerable decrease of experimental resources by simultaneously studying a full variation of composition. The results indicate a good biocompatibility for a nickel content up to about 50%. The cells used in the biocompatibility studies comprised osteoblast-like osteosarcoma cells (SAOS-2, MG-63), primary human osteoblasts (HOB), and murine fibroblasts (3T3). (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4549 / 4555
页数：7
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