The microbial epigenome in metabolic syndrome

被引：25

作者：

Remely, Marlene ^{[1
]}

Haslberger, Alexander G. ^{[1
]}

机构：

[1] Univ Vienna, Dept Nutr Sci, Vienna, Austria

来源：

MOLECULAR ASPECTS OF MEDICINE | 2017年 / 54卷

基金：

奥地利科学基金会;

关键词：

Firmicutes/Bacteroidetes ratio; SCFAs; DNA methylation; Obesity; CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR; COA-TRANSFERASE GENES; TUMOR-NECROSIS-FACTOR; DIET-INDUCED OBESITY; GUT MICROBIOTA; EPIGENETIC REGULATION; ADIPOSE-TISSUE; WEIGHT-GAIN; INSULIN-RESISTANCE;

D O I：

10.1016/j.mam.2016.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dietary habits, lifestyle, medication, and food additives affect the composition and functions of the GI microbiota. Metabolic syndrome is already known to be associated with an aberrant gut microbiota affecting systemic low-grade inflammation, which is also outlined by differing epigenetic patterns. Thus, structural changes and compositional evaluation of gut microbial differences affecting epigenetic patterns in metabolic syndrome are of research interest. In the present review we focus on the disparities in the gut microbiota composition of metabolic syndrome and the resulting aberrant profile of bioactive microbial metabolites known to affect epigenetic modifications such as G-protein coupled receptors and inflammatory pathways. (C) 2016 Elsevier Ltd. All rights reserved.

引用

收藏

页码：71 / 77

页数：7

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