The microbial epigenome in metabolic syndrome

被引：24
作者：
Remely, Marlene [1 ]
Haslberger, Alexander G. [1 ]
机构：
[1] Univ Vienna, Dept Nutr Sci, Vienna, Austria
来源：
MOLECULAR ASPECTS OF MEDICINE | 2017年 / 54卷
基金：
奥地利科学基金会;
关键词：
Firmicutes/Bacteroidetes ratio; SCFAs; DNA methylation; Obesity; CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR; COA-TRANSFERASE GENES; TUMOR-NECROSIS-FACTOR; DIET-INDUCED OBESITY; GUT MICROBIOTA; EPIGENETIC REGULATION; ADIPOSE-TISSUE; WEIGHT-GAIN; INSULIN-RESISTANCE;
D O I：
10.1016/j.mam.2016.09.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dietary habits, lifestyle, medication, and food additives affect the composition and functions of the GI microbiota. Metabolic syndrome is already known to be associated with an aberrant gut microbiota affecting systemic low-grade inflammation, which is also outlined by differing epigenetic patterns. Thus, structural changes and compositional evaluation of gut microbial differences affecting epigenetic patterns in metabolic syndrome are of research interest. In the present review we focus on the disparities in the gut microbiota composition of metabolic syndrome and the resulting aberrant profile of bioactive microbial metabolites known to affect epigenetic modifications such as G-protein coupled receptors and inflammatory pathways. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：71 / 77
页数：7
相关论文
共 83 条
  • [1] Interleukin-6 CpG Methylation and Body Weight Correlate Differently in Type 2 Diabetes Patients Compared to Obese and Lean Controls
    Aumueller, Eva
    Remely, Marlene
    Baeck, Hanna
    Hippe, Berit
    Brath, Helmut
    Haslberger, Alexander G.
    [J]. JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS, 2015, 8 (01) : 26 - 35
  • [2] The gut microbiota as an environmental factor that regulates fat storage
    Bäckhed, F
    Ding, H
    Wang, T
    Hooper, LV
    Koh, GY
    Nagy, A
    Semenkovich, CF
    Gordon, JI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) : 15718 - 15723
  • [3] Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content
    Bellahcene, Mohamed
    O'Dowd, Jacqueline F.
    Wargent, Ed T.
    Zaibi, Mohamed S.
    Hislop, David C.
    Ngala, Robert A.
    Smith, David M.
    Cawthorne, Michael A.
    Stocker, Claire J.
    Arch, Jonathan R. S.
    [J]. BRITISH JOURNAL OF NUTRITION, 2013, 109 (10) : 1755 - 1764
  • [4] The indigenous gastrointestinal microflora
    Berg, RD
    [J]. TRENDS IN MICROBIOLOGY, 1996, 4 (11) : 430 - 435
  • [5] Differences in gut microbiota composition between obese and lean children: a cross-sectional study
    Bervoets, Liene
    Van Hoorenbeeck, Kim
    Kortleven, Ineke
    Van Noten, Caroline
    Hens, Niel
    Vael, Carl
    Goossens, Herman
    Desager, Kristine N.
    Vankerckhoven, Vanessa
    [J]. GUT PATHOGENS, 2013, 5
  • [6] The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
    Briscoe, CP
    Tadayyon, M
    Andrews, JL
    Benson, WG
    Chambers, JK
    Eilert, MM
    Ellis, C
    Elshourbagy, NA
    Goetz, AS
    Minnick, DT
    Murdock, PR
    Sauls, HR
    Shabon, U
    Spinage, LD
    Strum, JC
    Szekeres, PG
    Tan, KB
    Way, JM
    Ignar, DM
    Wilson, S
    Muir, AI
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) : 11303 - 11311
  • [7] The epigenetic effects of butyrate: potential therapeutic implications for clinical practice
    Canani, Roberto Berni
    Di Costanzo, Margherita
    Leone, Ludovica
    [J]. CLINICAL EPIGENETICS, 2012, 4
  • [8] Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    Cani, Patrice D.
    Bibiloni, Rodrigo
    Knauf, Claude
    Neyrinck, Audrey M.
    Neyrinck, Audrey M.
    Delzenne, Nathalle M.
    Burcelin, Remy
    [J]. DIABETES, 2008, 57 (06) : 1470 - 1481
  • [9] Metabolic endotoxemia initiates obesity and insulin resistance
    Cani, Patrice D.
    Amar, Jacques
    Iglesias, Miguel Angel
    Poggi, Marjorie
    Knauf, Claude
    Bastelica, Delphine
    Neyrinck, Audrey M.
    Fava, Francesca
    Tuohy, Kieran M.
    Chabo, Chantal
    Waget, Aurelie
    Delmee, Evelyne
    Cousin, Beatrice
    Sulpice, Thierry
    Chamontin, Bernard
    Ferrieres, Jean
    Tanti, Jean-Francois
    Gibson, Glenn R.
    Casteilla, Louis
    Delzenne, Nathalie M.
    Alessi, Marie Christine
    Burcelin, Remy
    [J]. DIABETES, 2007, 56 (07) : 1761 - 1772
  • [10] Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota
    Cani, Patrice D.
    Delzenne, Nathalie M.
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (06) : 737 - 743
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