共 56 条
Ena/VASP: towards resolving a pointed controversy at the barbed end
被引:206
作者:

Bear, James E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

Gertler, Frank B.
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h-index: 0
机构:
MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
机构:
[1] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
[3] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
关键词:
Ena/VASP;
VASP;
Mena;
Actin;
Capping;
Filopodia;
Lamellipodia;
VASODILATOR-STIMULATED PHOSPHOPROTEIN;
ACTIN-BASED MOTILITY;
ARP2/3;
COMPLEX;
LISTERIA-MONOCYTOGENES;
FILAMENT ELONGATION;
FIBROBLAST MOTILITY;
FILOPODIA FORMATION;
DENDRITIC NETWORK;
IN-VIVO;
PROTEINS;
D O I:
10.1242/jcs.038125
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in several physiological processes such as morphogenesis, axon guidance, endothelial barrier function, and cancer cell invasion and metastasis. Although considerable evidence points towards an anti-capping mechanism for Ena/VASP function, some controversy remains. Here, we evaluate the evidence for and against the anti-capping hypothesis, including results from some recent structural and biochemical studies that shed new light on this issue. In addition, we describe several alternate mechanisms that Ena/VASP proteins may utilize to regulate actin dynamics in vivo, including inhibition of branching, bundling and profilin-actin recruitment.
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收藏
页码:1947 / 1953
页数:7
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