Heart Failure and Adverse Drug Reactions Among Hospitalized Older Adults

被引：25

作者：

Catananti, C. ^{[1
]}

Liperoti, R. ^{[1
]}

Settanni, S. ^{[1
]}

Lattanzio, F. ^{[2
]}

Bernabei, R. ^{[1
]}

Fialova, D. ^{[3
]}

Landi, F. ^{[1
]}

Onder, G. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Geriatr, Ctr Med Invecchiamento, Rome, Italy

[2] Italian Natl Res Ctr Aging, Res Dept, Ancona, Italy

[3] Charles Univ Prague, Dept Geriatr & Gerontol, Fac Med 1, Prague, Czech Republic

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 03期

关键词：

COGNITIVE IMPAIRMENT; DIGITALIS THERAPY; SERUM CREATININE; RISK-FACTORS; EVENTS; ASSOCIATION; POPULATION; MORTALITY; ADMISSION; REASONS;

D O I：

10.1038/clpt.2009.89

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to assess whether heart failure (HF) could be a risk factor for adverse drug reactions (ADRs) among hospitalized older adults. This study included 19,496 patients admitted to community-and university-based hospitals in Italy (mean age 70 +/- 14 years; 49.7% female). ADRs were identified in 207 of the 2,413 (8.6%) patients with HF and in 855 (5.0%) of the 17,083 patients without HF (P < 0.001). after adjusting for potential confounders, HF was shown to be associated with an increased likelihood of experiencing an ADR (odds ratio (or) 1.29; 95% confidence interval (CI) 1.06-1.56). after stratifying the sample by gender, the association continued to be seen in the women (or 1.58; 95% CI 1.22-2.05) but not in the men (or 0.99; 95% CI 0.74-1.34). in conclusion, HF appears to be associated with a higher rate of ADRs among hospitalized patients. gender may influence the effect of HF on the risk of ADRs.

引用

页码：307 / 310

页数：4

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