Bisphosphonates prevent experimental vascular calcification: Treat the bone to cure the vessels?

被引：45
作者：
Persy, V.
De Broe, M.
Ketteler, M.
机构：
[1] Univ Antwerp, Dept Pathophysiol, B-2610 Antwerp, Belgium
[2] Univ Hosp Aachen, Dept Nephrol, Rhein Westfal TH Aachen, D-5100 Aachen, Germany
来源：
KIDNEY INTERNATIONAL | 2006年 / 70卷 / 09期
关键词：
D O I：
10.1038/sj.ki.5001899
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Bisphosphonates are inhibitors of bone resorption that are widely used to treat osteoporosis. Price and colleagues demonstrate that ibandronate suppressed the development of uremia-related vascular calcification in rats. These findings extend the link between bone remodeling and vascular calcification to the context of chronic renal failure, opening perspectives toward novel therapeutic strategies.
引用
收藏
页码：1537 / 1538
页数：3
相关论文
共 14 条
[1]   osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification [J].
Bucay, N ;
Sarosi, I ;
Dunstan, CR ;
Morony, S ;
Tarpley, J ;
Capparelli, C ;
Scully, S ;
Tan, HL ;
Xu, WL ;
Lacey, DL ;
Boyle, WJ ;
Simonet, WS .
GENES & DEVELOPMENT, 1998, 12 (09) :1260-1268
[2]   Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome [J].
Davies, MR ;
Lund, RJ ;
Mathew, S ;
Hruska, KA .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (04) :917-928
[3]   Bisphosphonates: Mechanisms of action [J].
Fleisch, H .
ENDOCRINE REVIEWS, 1998, 19 (01) :80-100
[4]   Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo [J].
Giuliani, N ;
Pedrazzoni, M ;
Negri, G ;
Passeri, G ;
Impicciatore, M ;
Girasole, G .
BONE, 1998, 22 (05) :455-461
[5]   Inhibition of the progression of aortic calcification by etidronate treatment in hemodialysis patients: Long-term effects [J].
Hashiba, H ;
Aizawa, S ;
Tamura, K ;
Kogo, H .
THERAPEUTIC APHERESIS AND DIALYSIS, 2006, 10 (01) :59-64
[6]   Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats [J].
Katsumata, K ;
Kusano, K ;
Hirata, M ;
Tsunemi, K ;
Nagano, N ;
Burke, SK ;
Fukushima, N .
KIDNEY INTERNATIONAL, 2003, 64 (02) :441-450
[7]   Reduced plasma pyrophosphate levels in hemodialysis patients [J].
Lomashvili, KA ;
Khawandi, W ;
O'Neill, WC .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (08) :2495-2500
[8]   Arterial media calcification in end-stage renal disease:: impact on all-cause and cardiovascular mortality [J].
London, GM ;
Guérin, AP ;
Marchais, SJ ;
Métivier, F ;
Pannier, B ;
Adda, H .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2003, 18 (09) :1731-1740
[9]   Rapid improvement of calciphylaxis after intravenous pamidronate therapy in a patient with chronic renal failure [J].
Monney, P ;
Nguyen, QV ;
Perroud, H ;
Descombes, E .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2004, 19 (08) :2130-2132
[10]   Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis [J].
Nitta, K ;
Akiba, T ;
Suzuki, K ;
Uchida, K ;
Watanabe, RI ;
Majima, K ;
Aoki, T ;
Nihei, H .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 44 (04) :680-688
12