Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis

被引：46

作者：

Nakamoto, Kazuo ^{[1
,2
]}

Takayama, Fusako ^{[1
]}

Mankura, Mitsumasa ^{[2
,3
]}

Hidaka, Yuki ^{[1
,2
,3
]}

Egashira, Toru ^{[2
]}

Ogino, Tetsuya ^{[2
]}

Kawasaki, Hiromu ^{[1
]}

Mori, Akitane ^{[2
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

[3] Ikeda Tohka Ind Co Ltd, Res Lab, Fukuyama, Hiroshima 7210956, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2009年 / 44卷 / 03期

关键词：

non-alcoholic steatohepatitis; antioxidant; oxidative stress; hepatoprotection; FATTY LIVER-DISEASE; ISCHEMIA-REPERFUSION;

D O I：

10.3164/jcbn.08-256

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Oxidative stress is frequently considered as a central mechanism of hepatocellular injury in non-alcoholic steatohepatitis (NASH). The aim of this study was to investigate the effects of fermented green tea extracts (FGTE) on NASH. Rats were fed a choline-deficient high-fat diet for 4 weeks to nutritionally generate fatty livers. NASH was induced chemically by oxidative stress using repeated intraperitoneal injections of nitrite. Rats with NASH developed steatohepatitis and liver fibrosis after 6-week of such treatment. At 10 weeks, blood and liver samples were collected from anesthetized animals and assessed for extent of OS injury and effects of FGTE, by biochemical, histological and histochemical analyses. FGTE reduced serum levels of liver enzymes, lipid peroxidation and production of mitochondrial reactive oxygen species. In addition, FGTE showed inhibition of progressions of cirrhosis. Our findings suggest that our FETE have strong radical scavenging activity and may be beneficial in the prevention of NASH progression.

引用

页码：239 / 246

页数：8

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