Profiling cathepsin D and BACE2: Flap dynamics and interaction with a BACE1 inhibitor

被引：0
|
作者：
Shen, Jana [1 ]
Henderson, Jack [1 ]
Tsai, Cheng-Chieh [1 ]
机构：
[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 255卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
151
引用
收藏
页数：1
相关论文
共 50 条
  • [1] A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility
    Kumalo, H. M.
    Soliman, Mahmoud E.
    JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2016, 36 (05) : 505 - 514
  • [2] BACE1 and BACE2 deficient mice
    Dominguez, DI
    Tournoy, JU
    Hartmann, D
    Reiss, K
    Saftig, P
    de Strooper, B
    NEUROBIOLOGY OF AGING, 2004, 25 : S247 - S248
  • [3] In vivo consequences of BACE1 and BACE2 deficiency
    Tournoy, J
    Dominguez, D
    Hartmann, D
    Reiss, K
    Saftig, P
    De Strooper, B
    NEUROBIOLOGY OF AGING, 2004, 25 : S259 - S259
  • [4] BACE1 and BACE2 in pathologic and normal human muscle
    Vattemi, G
    Engel, WK
    McFerrin, J
    Pastorino, L
    Buxbaum, JD
    Askanas, V
    EXPERIMENTAL NEUROLOGY, 2003, 179 (02) : 150 - 158
  • [5] BACE1 and BACE2 enzymatic activities in Alzheimer's disease
    Ahmed, Rachel R.
    Holler, Christopher J.
    Webb, Robin L.
    Li, Feng
    Beckett, Tina L.
    Murphy, M. Paul
    JOURNAL OF NEUROCHEMISTRY, 2010, 112 (04) : 1045 - 1053
  • [6] Association studies using novel polymorphisms in BACE1 and BACE2
    Nowotny, P
    Kwon, JM
    Chakraverty, S
    Nowotny, V
    Morris, JC
    Goate, AM
    NEUROREPORT, 2001, 12 (09) : 1799 - 1802
  • [7] Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor
    Ellis, Christopher R.
    Tsai, Cheng-Chieh
    Lin, Fang-Yu
    Shen, Jana
    JOURNAL OF COMPUTATIONAL CHEMISTRY, 2017, 38 (15) : 1260 - 1269
  • [8] Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells
    Debomoy K. Lahiri
    Bryan Maloney
    Yuan-Wen Ge
    Journal of Molecular Neuroscience, 2006, 29 : 65 - 80
  • [9] Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells
    Lahiri, Debomoy K.
    Maloney, Bryan
    Ge, Yuan-Wen
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2006, 29 (01) : 65 - 80
  • [10] BACE1 and BACE2: exclusion of allele association with Alzheimer's disease
    Giannakopoulos, P
    Herrmann, F
    Gold, G
    Bouras, C
    Mulligan, R
    Duriaux-Sail, G
    Michon, A
    Antonarakis, SE
    Blouin, JL
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2002, 10 : 267 - 267
12345