IL-18 and Cutaneous Inflammatory Diseases

被引：74
作者：
Lee, Ji Hyun [1 ]
Cho, Dae Ho [2 ]
Park, Hyun Jeong [3 ]
机构：
[1] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Dermatol, Seoul 137701, South Korea
[2] Sookmyung Womens Univ, Dept Life Sci, Seoul 140742, South Korea
[3] Catholic Univ Korea, Coll Med, Yeouido St Marys Hosp, Dept Dermatol, Seoul 150713, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
IL-18; psoriasis; atopic dermatitis; urticaria; contact dermatitis; alopecia areata; drug eruption; lupus erythematosus; fibrosis; graft-versus-host disease; skin tumor; skin disease; CORTICOTROPIN-RELEASING HORMONE; INTERLEUKIN-18 PROMOTER POLYMORPHISMS; ALLERGIC CONTACT-DERMATITIS; VERSUS-HOST-DISEASE; ATOPIC-DERMATITIS; ALOPECIA-AREATA; DENDRITIC CELLS; PROTEIN EXPRESSION; INNATE IMMUNITY; SERUM-LEVELS;
D O I：
10.3390/ijms161226172
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.
引用
收藏
页码：29357 / 29369
页数：13
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