Microglial Cells as a Link between Cannabinoids and the Immune Hypothesis of Psychiatric Disorders

被引：47
作者：
Lisboa, Sabrina F. [1 ,2 ]
Gomes, Felipe V. [3 ]
Guimaraes, Francisco S. [1 ,2 ]
Campos, Alline C. [1 ,2 ]
机构：
[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pharmacol, BR-14049 Ribeirao Preto, Brazil
[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-14049 Ribeirao Preto, Brazil
[3] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA USA
来源：
FRONTIERS IN NEUROLOGY | 2016年 / 7卷
基金：
巴西圣保罗研究基金会;
关键词：
microglia; glia; cannabinoids; anxiety; depression; schizophrenia; DEPRESSIVE-LIKE BEHAVIOR; CENTRAL-NERVOUS-SYSTEM; FACTOR-KAPPA-B; CB2; RECEPTOR; DOUBLE-BLIND; ENDOCANNABINOID SYSTEM; PSYCHOLOGICAL STRESS; MONOCYTE TRAFFICKING; PREFRONTAL CORTEX; BIPOLAR DISORDER;
D O I：
10.3389/fneur.2016.00005
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Psychiatric disorders are one of the leading causes of disability worldwide. Although several therapeutic options are available, the exact mechanisms responsible for the genesis of these disorders remain to be fully elucidated. In the last decade, a body of evidence has supported the involvement of the immune system in the pathophysiology of these conditions. Microglial cells play a significant role in maintaining brain homeostasis and surveillance. Dysregulation of microglial functions has been associated with several psychiatric conditions. Cannabinoids regulate the brain immune axis and inhibit microglial cell activation. Here, we summarized evidence supporting the hypothesis that microglial cells could be a target for cannabinoid influence on psychiatric disorders, such as anxiety, depression, schizophrenia, and stress-related disorders.
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页数：8
相关论文
共 144 条
[1]   CLINICAL TRIAL OF ADJUNCTIVE CELECOXIB TREATMENT IN PATIENTS WITH MAJOR DEPRESSION: A DOUBLE BLIND AND PLACEBO CONTROLLED TRIAL [J].
Akhondzadeh, Shahin ;
Jafari, Sara ;
Raisi, Firoozeh ;
Nasehi, Abbas Ali ;
Ghoreishi, Aboulfazl ;
Salehi, Bahman ;
Mohebbi-Rasa, Soodeh ;
Raznahan, Maedeh ;
Kamalipour, Abbas .
DEPRESSION AND ANXIETY, 2009, 26 (07) :607-611
[2]   Cannabinoids and glucocorticoids modulate emotional memory after stress [J].
Akirav, Irit .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2013, 37 (10) :2554-2563
[3]   Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain [J].
Alliot, F ;
Godin, I ;
Pessac, B .
DEVELOPMENTAL BRAIN RESEARCH, 1999, 117 (02) :145-152
[4]   Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery [J].
Arevalo-Martin, Angel ;
Garcia-Ovejero, Daniel ;
Sierra-Palomares, Yolanda ;
Paniagua-Torija, Beatriz ;
Gonzalez-Gil, Ines ;
Ortega-Gutierrez, Silvia ;
Molina-Holgado, Eduardo .
PLOS ONE, 2012, 7 (11)
[5]  
Ashton JC, 2007, CURR OPIN INVEST DR, V8, P373
[6]   Social Interactions, Stress, and Immunity [J].
Avitsur, Ronit ;
Powell, Nicole ;
Padgett, David A. ;
Sheridan, John F. .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2009, 29 (02) :285-+
[7]   IL-6 levels decrease with SSRI treatment in patients with major depression [J].
Basterzi, AD ;
Aydemir, Ç ;
Kisa, C ;
Aksaray, S ;
Tuzer, V ;
Yazici, K ;
Göka, E .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2005, 20 (07) :473-476
[8]   Evidence for activation of microglia in patients with psychiatric illnesses [J].
Bayer, TA ;
Buslei, R ;
Havas, L ;
Falkai, P .
NEUROSCIENCE LETTERS, 1999, 271 (02) :126-128
[9]   Sex-dependent long-term effects of adolescent exposure to THC and/or MDMA on neuroinflammation and serotoninergic and cannabinoid systems in rats [J].
Belen Lopez-Rodriguez, Ana ;
Llorente-Berzal, Alvaro ;
Garcia-Segura, Luis M. ;
Viveros, Maria-Paz .
BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (06) :1435-1447
[10]   The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes [J].
Beumer, Wouter ;
Gibney, Sinead M. ;
Drexhage, Roosmarijn C. ;
Pont-Lezica, Lorena ;
Doorduin, Janine ;
Klein, Hans C. ;
Steiner, Johann ;
Connor, Thomas J. ;
Harkin, Andrew ;
Versnel, Marjan A. ;
Drexhage, Hemmo A. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2012, 92 (05) :959-975
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