CD6-ligand interactions: a paradigm for SRCR domain function?

被引：134
作者：
Aruffo, A
Bowen, MA
Patel, DD
Haynes, BF
Starling, GC
Gebe, JA
Bajorath, J
机构：
[1] DUKE UNIV,SCH MED,DEPT MED,DURHAM,NC 27710
[2] UNIV WASHINGTON,DEPT BIOL STRUCT,SEATTLE,WA 98195
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 10期
关键词：
D O I：
10.1016/S0167-5699(97)01130-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.
引用
收藏
页码：498 / 504
页数：7
相关论文
共 44 条
[1]   THE LYMPHOCYTE GLYCOPROTEIN-CD6 CONTAINS A REPEATED DOMAIN-STRUCTURE CHARACTERISTIC OF A NEW FAMILY OF CELL-SURFACE AND SECRETED PROTEINS [J].
ARUFFO, A ;
MELNICK, MB ;
LINSLEY, PS ;
SEED, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (04) :949-952
[2]   MOLECULAR-MODEL OF THE N-TERMINAL RECEPTOR-BINDING DOMAIN OF THE HUMAN CD6 LIGAND ALCAM [J].
BAJORATH, J ;
BOWEN, MA ;
ARUFFO, A .
PROTEIN SCIENCE, 1995, 4 (08) :1644-1647
[3]   Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes [J].
Biancone, L ;
Bowen, MA ;
Lim, A ;
Aruffo, A ;
Andres, G ;
Stamenkovic, I .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :811-819
[4]   Identification of residues in CD6 which are critical for ligand binding [J].
Bodian, DL ;
Skonier, JE ;
Bowen, MA ;
Neubauer, M ;
Siadak, AW ;
Aruffo, A ;
Bajorath, J .
BIOCHEMISTRY, 1997, 36 (09) :2637-2641
[5]  
BOTT CM, 1993, INT IMMUNOL, V7, P783
[6]  
Bowen MA, 1997, J IMMUNOL, V158, P1149
[7]   The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry [J].
Bowen, MA ;
Bajorath, J ;
Siadak, AW ;
Modrell, B ;
Malacko, AR ;
Marquardt, H ;
Nadler, SG ;
Aruffo, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (29) :17390-17396
[8]   CLONING, MAPPING, AND CHARACTERIZATION OF ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE (ALCAM), A CD6 LIGAND [J].
BOWEN, MA ;
PATEL, DD ;
LI, X ;
MODRELL, B ;
MALACKO, AR ;
WANG, WC ;
MARQUARDT, H ;
NEUBAUER, M ;
PESANDO, JM ;
FRANCKE, U ;
HAYNES, BF ;
ARUFFO, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (06) :2213-2220
[9]  
BOWEN MA, IN PRESS EUR J IMMUN
[10]  
CAMPBELL IG, 1994, CANCER RES, V54, P5761
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