Cutaneous drug reactions: pharmacogenetic news

被引：0

作者：

Buffard, V ^{[1
]}

Roujeau, JC

机构：

[1] Hop Henri Mondor, Dermatol Serv, F-94000 Creteil, France

[2] INSERM, U448, F-75654 Paris 13, France

来源：

ARCHIVES DE PEDIATRIE | 2004年 / 11卷 / 05期

关键词：

toxic epidermal necrolysis; drug hypersensitivity; drug metabolism; acetylation; HLA;

D O I：

10.1016/j.arcped.2004.02.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Identifying genetic factors in severe drug eruption should improve efficacy and safety of drug prescription. The first pharmacogenetic studies concerned the polymorphism of genes encoding drug metabolism enzymes (especially for sulfamides reactions in AIDS and anticonvulsants reactions). Recent studies did not confirm the role of genotypic variation in metabolism enzymes in drug reaction. Genes controlling immune response are another research issue. Certain MHC phenotypes are linked to a higher risk of toxidermy, such as in abacavir hypersensitivity or fixed drug eruption. Indeed, severe drug eruptions seem to be linked to a specific immune response controlled by T lymphocytes. (C) 2004 Elsevier SAS. Tous droits reserves.

引用

页码：489 / 492

页数：4

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