Geminal hydroxy phosphonate derivatives of nucleosides:: A novel class of nucleoside 5′-monophosphate analogues

被引：23
|
作者：
Králíková, S [1 ]
Budesínsky, M [1 ]
Masojídková, M [1 ]
Rosenberg, I [1 ]
机构：
[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0040-4039(99)02107-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel type of phosphonate-based, isopolar, nonisosteric 5'-nucleotide analogue, the nucleoside 5'-hydroxy phosphonates, was prepared by Abramov nucleophilic addition of various phosphorous acid esters to nucleoside 5'-aldehydes. The newly formed compounds are distinguished by chirality of the 5'-carbon atom. The configuration of the 5'-epimers was assigned from NMR spectra. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：955 / 958
页数：4
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