Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells

被引：227

作者：

Rodrigues, Patrick Fernandes ^{[1
]}

Alberti-Servera, Llucia ^{[1
,2
,3
]}

Eremin, Anna ^{[1
]}

Grajales-Reyes, Gary E. ^{[4
]}

Ivanek, Robert ^{[1
,5
]}

Tussiwand, Roxane ^{[1
]}

机构：

[1] Univ Basel, Dept Biomed, Basel, Switzerland

[2] Dept Human Genet, Leuven, Belgium

[3] VIB Ctr Biol Dis, Leuven, Belgium

[4] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[5] Swiss Inst Bioinformat, Basel, Switzerland

来源：

NATURE IMMUNOLOGY | 2018年 / 19卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

INTERFERON-PRODUCING CELLS; TRANSCRIPTION FACTOR E2-2; IN-VIVO; BONE-MARROW; HEMATOPOIETIC PROGENITOR; COMMITTED PROGENITORS; CLONOGENIC PROGENITOR; REGULATORY FACTOR-4; SUBSET DEVELOPMENT; REPRESSING ID2;

D O I：

10.1038/s41590-018-0136-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R(+) lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. Transcriptional characterization of SiglecH(+) Ly6D(+) precursors indicated that pDC development requires high expression of the transcription factor IRF8, whereas pDC identity relies on TCF4. RNA sequencing of IL-7R(+) lymphoid and CDP-derived pDCs mirrored the heterogeneity of mature pDCs observed in single-cell analysis. Both mature pDC subsets are able to secrete type 1 interferons, but only myeloid-derived pDCs share with cDCs their ability to process and present antigen.

引用

页码：711 / +

页数：14

共 65 条

[1] Frontline:: A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential [J].