Monofunctionalization of calix[4]arene tetracarboxylic acid at the upper rim with isothiocyanate group: First bifunctional chelating agent for alpha-emitter Ac-225

被引：0

作者：

Chen, XY

Ji, M

Fisher, DR

Wai, CM ^{[1
]}

机构：

[1] Univ Idaho, Dept Chem, Moscow, ID 83844 USA

[2] PNNL, Hanford Radioisotopes & Med Sci Program, Richland, WA 99352 USA

来源：

SYNLETT | 1999年 / 11期

关键词：

actinium-225; bifunctional chelating agents; calixarenes; isothiocyanate;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

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页码：1784 / 1786

页数：3

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