A Concise Approach Toward Tetrazolyl-Substituted Benzazocines via a Novel Isocyanide-Based Multicomponent Reaction

被引：16

作者：

Borisov, Roman S. ^{[1
]}

Voskressensky, Leonid G. ^{[2
]}

Polyakov, Anatoly I. ^{[3
]}

Borisova, Tatiana N. ^{[2
]}

Varlamov, Alexey V. ^{[2
]}

机构：

[1] Russian Acad Sci, AV Topchiev Inst Petrochem Synth, Moscow 119991, Russia

[2] Peoples Friendship Univ Russia, Moscow 117198, Russia

[3] Russian Acad Sci, NN Blohin Canc Res Ctr, Moscow 119991, Russia

来源：

SYNLETT | 2014年 / 25卷 / 07期

基金：

俄罗斯基础研究基金会;

关键词：

alkaloids; multicomponent reaction; domino reaction; ring expansion; alkynes; NATURAL-PRODUCTS; DRUG DISCOVERY; TETRAHYDROPYRIDINE RING; CONDENSATION; TEMPLATES; LIBRARIES; COTARNINE; EFFICIENT; FUTURE; ACID;

D O I：

10.1055/s-0033-1340861

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of pharmacologically relevant isoquinoline-tetrazoles and benzazocine-tetrazoles via sequential azido-Ugi and alkyne-induced ring-expansion reactions starting from cotarnine chloride are reported. A one-pot, multicomponent reaction protocol toward the ring-expanded product is also described.

引用

页码：955 / 958

页数：4

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