Epiregulin: Roles in normal physiology and cancer

被引：141

作者：

Riese, David J., II ^{[1
]}

Cullum, Richard L. ^{[2
]}

机构：

[1] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA

[2] Samuel Ginn Coll Engn, Dept Chem Engn, Auburn, AL 36849 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 28卷

关键词：

Epiregulin; EGF/ErbB receptors; Oocyte maturation; Inflammation; Tumor Progression; Epithelial cell proliferation; EPIDERMAL-GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; FACTOR RECEPTOR; EGFR LIGANDS; FACTOR FAMILY; DIFFERENTIAL EXPRESSION; INFLAMMATORY RESPONSES; PARTIAL AGONISTS; ERBB RECEPTORS; FACTOR NETWORK;

D O I：

10.1016/j.semcdb.2014.03.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epiregulin is a 46-amino acid protein that belongs to the epidermal growth factor (EGF) family of peptide hormones. Epiregulin binds to the EGF receptor (EGFR/ErbB1) and ErbB4 (HER4) and can stimulate signaling of ErbB2 (HER2/Neu) and ErbB3 (HER3) through ligand-induced heterodimerization with a cognate receptor. Epiregulin possesses a range of functions in both normal physiologic states as well as in pathologic conditions. Epiregulin contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. Deregulated epiregulin activity appears to contribute to the progression of a number of different malignancies, including cancers of the bladder, stomach, colon, breast, lung, head and neck, and liver. Therefore, epiregulin and the elements of the EGF/ErbB signaling network that lie downstream of epiregulin appear to be good targets for therapeutic intervention. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：49 / 56

页数：8

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