Isavuconazole Therapy Protects Immunosuppressed Mice from Mucormycosis

被引：62

作者：

Luo, Guanpingsheng ^{[1
,2
]}

Gebremariam, Teclegiorgis ^{[1
,2
]}

Lee, Hongkyu ^{[1
,2
]}

Edwards, John E., Jr. ^{[1
,2
,3
]}

Kovanda, Laura ^{[4
]}

Ibrahim, Ashraf S. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, Div Infect Dis, Los Angeles Biomed Res Inst Harbor, Med Ctr, Torrance, CA USA

[2] St Johns Cardiovasc Res Ctr, Torrance, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[4] Astellas Pharma Global Dev Inc, Northbrook, IL USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 04期

关键词：

IN-VITRO ACTIVITY; LIPOSOMAL AMPHOTERICIN-B; EUROPEAN COMMITTEE; ANTIFUNGAL AGENTS; IMPROVES SURVIVAL; QUANTITATIVE PCR; ACTIVE COMPONENT; TRIAZOLE BAL4815; MOLD INFECTIONS; MURINE MODEL;

D O I：

10.1128/AAC.02301-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied the in vitro and in vivo efficacies of the investigational drug isavuconazole against mucormycosis due to Rhizopus delemar. Isavuconazole was effective, with MIC and minimal fungicidal concentration (MFC) values ranging between 0.125 and 1.00 mu g/ml. A high dose of isavuconazole prolonged the survival time and lowered the tissue fungal burden of cyclophosphamide/cortisone acetate-treated mice infected with R. delemar and was as effective as a high-dose liposomal amphotericin B treatment. These results support the further development of this azole against mucormycosis.

引用

页码：2450 / 2453

页数：4

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