Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid

被引：36

作者：

Gao, Zhi-Ming ^{[1
]}

Zhu, Le-Ping ^{[1
]}

Yang, Xiao-Quan ^{[1
,2
]}

He, Xiu-Ting ^{[1
]}

Wang, Jin-Mei ^{[1
]}

Guo, Jian ^{[1
]}

Qi, Jun-Ru ^{[1
]}

Wang, Li-Juan ^{[1
]}

Yin, Shou-Wei ^{[1
]}

机构：

[1] S China Univ Technol, Res & Dev Ctr Food Prot, Dept Food Sci & Technol, Guangzhou 510640, Guangdong, Peoples R China

[2] S China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

FOOD & FUNCTION | 2014年 / 5卷 / 06期

关键词：

POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STABILITY; BETA-LACTOGLOBULIN; COMPLEX; MICROENCAPSULATION; EMULSIONS; ISOMERS; SYSTEMS; CLA; BIOAVAILABILITY;

D O I：

10.1039/c3fo60497g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Soy lipophilic protein nanoparticles (LPP), which present a novel delivery vehicle for conjugated linoleic acid (CLA), were fabricated by ultrasonication of the soy lipophilic protein (LP), which exhibits unique characteristics including a high loading capacity, oxidation protection and a sustained releasing profile in vitro for CLA. The CLA-loaded LPP exhibited a mean diameter of 170 +/- 0.63 nm and a loading capacity of 26.3 +/- 0.40% (w/w). A coating of sodium caseinate (SC) on the surface improved the colloidal stability of the CLA-loaded LPP. This encapsulation conferred protection against the oxidation of CLA, by which the head space-oxygen consumption and hydrogen peroxide value were obviously decreased in comparison with the SC-encapsulated CLA and CLA alone. The delivery system enables a sustained releasing profile of CLA in a simulated gastrointestinal tract (GIT). These findings illustrate that the LPP could act as an effective delivery device for CLA, which could provide oxidation stability and a sustained release property.

引用

页码：1286 / 1293

页数：8

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