Pharmacological Treatment of a Diffuse Arteriovenous Malformation of the Upper Extremity in a Child

被引：0

作者：

Burrows, Patricia E. ^{[1
]}

Mulliken, John B. ^{[2
,3
]}

Fishman, Steven J. ^{[2
,3
]}

Klement, Giannoula L. ^{[4
]}

Folkman, Judah ^{[2
,3
]}

机构：

[1] St Lukes Roosevelt Hosp, Dept Radiol, New York, NY 10025 USA

[2] Childrens Hosp Boston, Dept Surg, Boston, MA USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Childrens Hosp Boston, Vasc Anomalies Ctr, Dept Hematol Oncol, Boston, MA USA

来源：

JOURNAL OF CRANIOFACIAL SURGERY | 2009年 / 20卷

关键词：

Arteriovenous malformation; embolization; angiogenesis; matrix metalloproteinase inhibitor; marimastat; MATRIX-METALLOPROTEINASE INHIBITION; VASCULAR MALFORMATIONS; CONGENITAL ANGIODYSPLASIAS; ARTERIAL ENLARGEMENT; EMBOLIZATION THERAPY; GENE-EXPRESSION; PTEN MUTATIONS; GROWTH-FACTOR; FISTULA; CYANOACRYLATE;

D O I：

10.1097/SCS.0b013e3181927fle

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A young girl with an arteriovenous malformation involving the right tipper extremity developed rapidly progressive bony destruction that did not respond to embolization. Treatment with marimastat, starting at 3 years of age, resulted in rapid resolution of pain and gradual healing of bony destruction, associated with regression of the intraosseous arteriovenous shunts. New arteriovenous shunts with bony destruction developed over the years and responded to an increase in the dose of marimastat. Interruption of therapy resulted in recurrence of pain and formation of new lesions. The patient has been treated in this way for 12 years with no adverse effects from the drug.

引用

页码：597 / 602

页数：6

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