AMPK in the brain: its roles in energy balance and neuroprotection

被引：253

作者：

Ronnett, Gabriele V. ^{[1
,2
]}

Ramamurthy, Santosh ^{[1
]}

Kleman, Amy M. ^{[1
]}

Landree, Leslie E. ^{[1
]}

Aja, Susan ^{[3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, CMOR, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, CMOR, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2009年 / 109卷

关键词：

AMP-activated protein kinase; C75; energy balance; neurons; obesity; stroke; ACTIVATED PROTEIN-KINASE; FATTY-ACID SYNTHASE; ACETYL-COA CARBOXYLASE; NITRIC-OXIDE SYNTHASE; REDUCES FOOD-INTAKE; CELL-DEATH; VENTROMEDIAL HYPOTHALAMUS; ADENOSINE-MONOPHOSPHATE; EXTRACELLULAR GLUCOSE; METABOLIC CHECKPOINT;

D O I：

10.1111/j.1471-4159.2009.05916.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenosine monophosphate-activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the CNS. While all neurons sense their own energy status, some integrate neuro-humoral signals to assess organismal energy balance. A variety of disease states may involve AMPK, so determining the underlying mechanisms is important. We review the impact of altered AMPK activity under physiological (hunger, satiety) and pathophysiological (stroke) conditions, as well as therapeutic manipulations of AMPK that may improve energy balance.

引用

页码：17 / 23

页数：7

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