Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

被引：11

作者：

Herth, Matthias M. ^{[1
,2
,3
,4
]}

Leth-Petersen, Sebastian ^{[2
]}

Lehel, Szabolcs ^{[1
]}

Hansen, Martin ^{[2
]}

Knudsen, Gitte M. ^{[3
,4
]}

Gillings, Nic ^{[1
]}

Madsen, Jacob ^{[1
]}

Kristensen, Jesper L. ^{[2
]}

机构：

[1] Copenhagen Univ Hosp, Rigshosp, PET & Cyclotron Unit, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark

[3] Rigshosp, Ctr Integrated Mol Brain Imaging, DK-2100 Copenhagen, Denmark

[4] Univ Copenhagen, DK-2100 Copenhagen, Denmark

来源：

RSC ADVANCES | 2014年 / 4卷 / 41期

关键词：

DERIVATIVES; CHEMISTRY; MONOXIDE; LIBRARY;

D O I：

10.1039/c4ra02506g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report, herein, a simple and efficient labelling strategy for multiple PET tracer preparation using a common intermediate, which has the potential to accelerate preclinical PET radiotracer screening. This procedure was applied to and compared with a previously published labelling strategy illustrating the advantages of this newly developed combinatorial approach.

引用

页码：21347 / 21350

页数：4

共 26 条

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