Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer

被引:22
作者
Morita, Yoshihiro [1 ,2 ,5 ]
Morita, Nobuo [4 ,5 ]
Hata, Kenji [1 ]
Nakanishi, Masako [1 ]
Kimoto, Natsuko [3 ]
Omata, Tetsuji [3 ]
Nakamura, Yasushi
Yoneda, Toshiyuki [1 ]
机构
[1] Osaka Univ, Grad Sch Dent, Dept Mol & Cellular Biochem, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Dent, Dept Oral & Maxillofacial Surg, Suita, Osaka 5650871, Japan
[3] Social Insurance Kinan Hosp, Dept Oral & Maxillofacial Surg, Tanabe, Japan
[4] Wakayama Wellness Fdn, Dept Oral & Maxillofacial Surg, Wakayama, Japan
[5] Seichokai Hannan City Hosp, Dept Oral & Maxillofacial Surg, Hannan, Japan
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2014年 / 117卷 / 04期
关键词
SQUAMOUS-CELL CARCINOMA; VEGF-C; PROGNOSTIC-SIGNIFICANCE; IMMUNOHISTOCHEMICAL EXPRESSION; COX-2; EXPRESSION; LYMPHANGIOGENESIS; INVASION; HEAD; ANGIOGENESIS; OVEREXPRESSION;
D O I
10.1016/j.oooo.2013.12.410
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective. This study aimed to determine the relationship of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-c (VEGF-C) expression with lymphangiogenesis, lymph node metastasis (LNM), and other clinicopathologic features in human oral tongue cancers. Study Design. Forty tongue cancer specimens were immunohistochemically examined for COX-2 and VEGF-C expression and for lymphatic vessel density (LVD). We analyzed the relationships between COX-2 and VEGF-C expression and the relationships of such expression with clinicopathologic findings and survival of patients. Results. Eighteen tumors out of 40 (45%) showed COX-2 expression, and 18 tumors (45%) expressed VEGF-C. Twelve tumors (30%) coexpressed COX-2/VEGF-C. A significant correlation was found between COX-2 and VEGF-C expression (P < .01). Of note, COX-2/VEGF-C coexpression significantly correlated with lymphangiogenesis, LNM, TNM stage (P < .01), and LVD (P < .05). In Cox regression for survival, COX-2/VEGF-C coexpression was identified as an independent prognostic factor (P < .05). Conclusions. Our results suggest that examination of immunohistochemical expression of COX-2 and VEGF-C predicts LNM and survival in human oral tongue cancers.
引用
收藏
页码:502 / 510
页数:9
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