Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X-ray Computed Tomography Imaging

被引：85

作者：

Yin, Qian ^{[1
]}

Yap, Felix Y. ^{[4
]}

Yin, Lichen ^{[1
]}

Ma, Liang ^{[1
]}

Zhou, Qin ^{[5
]}

Dobrucki, Lawrence W. ^{[3
]}

Fan, Timothy M. ^{[2
]}

Gaba, Ron C. ^{[4
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[4] Univ Illinois, Dept Radiol, Chicago, IL 60612 USA

[5] Guangdong Pharmaceut Univ, Dept Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 37期

关键词：

GOLD NANOPARTICLES; DRUG-DELIVERY; CANCER; FORMULATION; POLYMERS;

D O I：

10.1021/ja405196f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanopartides exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.

引用

页码：13620 / 13623

页数：4

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