Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

被引：128

作者：

Oikarinen, Sami ^{[1
]}

Tauriainen, Sisko ^{[1
,2
]}

Hober, Didier ^{[3
,4
]}

Lucas, Bernadette ^{[3
,4
]}

Vazeou, Andriani ^{[5
]}

Sioofy-Khojine, Amirbabak ^{[1
]}

Bozas, Evangelos ^{[5
]}

Muir, Peter ^{[6
]}

Honkanen, Hanna ^{[1
]}

Ilonen, Jorma ^{[7
,8
]}

Knip, Mikael ^{[9
,10
,11
,12
,13
,14
]}

Keskinen, Paivi ^{[12
,13
]}

Saha, Marja-Terttu ^{[12
,13
]}

Huhtala, Heini ^{[15
]}

Stanway, Glyn ^{[16
]}

Bartsocas, Christos ^{[5
]}

Ludvigsson, Johnny ^{[17
]}

Taylor, Keith ^{[18
]}

Hyoty, Heikki ^{[1
,19
]}

机构：

[1] Univ Tampere, Dept Virol, FIN-33101 Tampere, Finland

[2] Univ Turku, Dept Virol, Turku, Finland

[3] Univ Lille 2, Lab Virol EA3610, Lille, France

[4] CHR, Lille, France

[5] Natl Tech Univ Athens, Dept Pediat, Fac Nursing, Athens, Greece

[6] Kings Coll London, London, England

[7] Univ Turku, Immunogenet Lab, Turku, Finland

[8] Univ Eastern Finland, Dept Clin Microbiol, Kuopio, Finland

[9] Folkhalsan Res Ctr, Helsinki, Finland

[10] Univ Helsinki, Childrens Hosp, Helsinki, Finland

[11] Helsinki Univ Cent Hosp, Helsinki, Finland

[12] Tampere Univ Hosp, Dept Pediat, Tampere, Finland

[13] Univ Tampere, FIN-33101 Tampere, Finland

[14] Univ Helsinki, Diabet & Obes Res Program, Helsinki, Finland

[15] Univ Tampere, Sch Hlth Sci, FIN-33101 Tampere, Finland

[16] Univ Essex, Dept Biol Sci, Colchester CO4 3SQ, Essex, England

[17] Linkoping Univ, Div Pediat, Dept Clin & Expt Med, Linkoping, Sweden

[18] Queen Mary Univ London, London E1 4NS, England

[19] Pirkanmaa Hosp Dist, Fimlab Labs, Tampere, Finland

来源：

DIABETES | 2014年 / 63卷 / 02期

基金：

芬兰科学院;

关键词：

CAPSID PROTEIN VP1; ENTEROVIRUS INFECTION; ISLET CELLS; MELLITUS; PANCREAS; CHILDREN; DISEASE; AUTOANTIBODIES; PATHOGENESIS; INDUCTION;

D O I：

10.2337/db13-0620

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.

引用

页码：655 / 662

页数：8

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