Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function

被引:13
作者
Hardman, Clare [1 ,2 ]
Chen, Wentao [3 ,4 ]
Luo, Jian [3 ,4 ]
Batty, Paul [3 ,4 ]
Chen, Yi-Ling [1 ,2 ]
Nahler, Janina [1 ,2 ]
Wu, Yanqiu [3 ,4 ]
Pavord, Ian D. [3 ,4 ]
Erpenbeck, Veit J. [5 ]
Sandham, David A. [6 ]
Xue, Luzheng [3 ,4 ]
Ogg, Graham [1 ,2 ]
机构
[1] Univ Oxford, MRC Human Immunol Unit, Oxford, England
[2] Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England
[3] Univ Oxford, Resp Med Unit, Oxford, England
[4] Univ Oxford, Oxford Biomed Res Ctr, Oxford, England
[5] Novartis Pharma AG, Basel, Switzerland
[6] Novartis Inst Biomed Res, Cambridge, MA USA
关键词
ASTHMA;
D O I
10.1016/j.jaci.2019.02.015
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:2329 / +
页数:6
相关论文
共 9 条
[1]  
Bateman ED, 2017, EUR RESPIR J, V50
[2]   Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation [J].
Fajt, Merritt L. ;
Gelhaus, Stacy L. ;
Freeman, Bruce ;
Uvalle, Crystal E. ;
Trudeau, John B. ;
Holguin, Fernando ;
Wenzel, Sally E. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (06) :1504-+
[3]   Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial [J].
Gonem, Sherif ;
Berair, Rachid ;
Singapuri, Amisha ;
Hartley, Ruth ;
Laurencin, Marie F. M. ;
Bacher, Gerald ;
Holzhauer, Bjorn ;
Bourne, Michelle ;
Mistry, Vijay ;
Pavord, Ian D. ;
Mansur, Adel H. ;
Wardlaw, Andrew J. ;
Siddiqui, Salman H. ;
Kay, Richard A. ;
Brightling, Christopher E. .
LANCET RESPIRATORY MEDICINE, 2016, 4 (09) :699-707
[4]   Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation [J].
Halim, Timotheus Y. F. ;
Steer, Catherine A. ;
Mathae, Laura ;
Gold, Matthew J. ;
Martinez-Gonzalez, Itziar ;
McNagny, Kelly M. ;
McKenzie, Andrew N. J. ;
Takei, Fumio .
IMMUNITY, 2014, 40 (03) :425-435
[5]   Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma [J].
Hilvering, Bart ;
Hinks, Timothy S. C. ;
Stoger, Linda ;
Marchi, Emanuele ;
Salimi, Maryam ;
Shrimanker, Rahul ;
Liu, Wei ;
Chen, Wentao ;
Luo, Jian ;
Go, Simei ;
Powell, Timothy ;
Cane, Jennifer ;
Thulborn, Samantha ;
Kurioka, Ayako ;
Leng, Tianqi ;
Matthews, Jamie ;
Connolly, Clare ;
Borg, Catherine ;
Bafadhel, Mona ;
Willberg, Christian B. ;
Ramasamy, Adaikalavan ;
Djukanovic, Ratko ;
Ogg, Graham ;
Pavord, Ian D. ;
Klenerman, Paul ;
Xue, Luzheng .
MUCOSAL IMMUNOLOGY, 2018, 11 (05) :1408-1419
[6]   Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin [J].
Kim, Brian S. ;
Wang, Kelvin ;
Siracusa, Mark C. ;
Saenz, Steven A. ;
Brestoff, Jonathan R. ;
Monticelli, Laurel A. ;
Noti, Mario ;
Wojno, Elia D. Tait ;
Fung, Thomas C. ;
Kubo, Masato ;
Artis, David .
JOURNAL OF IMMUNOLOGY, 2014, 193 (07) :3717-3725
[7]   Type 2 innate lymphoid cells in induced sputum from children with severe asthma [J].
Nagakumar, Prasad ;
Denney, Laura ;
Fleming, Louise ;
Bush, Andrew ;
Lloyd, Clare M. ;
Saglani, Sejal .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (02) :624-+
[8]   Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma [J].
Sandham, David A. ;
Barker, Lucy ;
Brown, Lyndon ;
Brown, Zarin ;
Budd, David ;
Charlton, Steven J. ;
Chatterjee, Devnandan ;
Cox, Brian ;
Dubois, Gerald ;
Duggan, Nicholas ;
Hall, Edward ;
Hatto, Julia ;
Maas, Janet ;
Manini, Jodie ;
Profit, Rachael ;
Riddy, Darren ;
Ritchie, Catherine ;
Sohal, Bindi ;
Shaw, Duncan ;
Stringer, Rowan ;
Sykes, David A. ;
Thomas, Matthew ;
Turner, Katharine L. ;
Watson, Simon J. ;
West, Ryan ;
Willard, Elisabeth ;
Williams, Gareth ;
Willis, Jennifer .
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (05) :582-586
[9]   Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells [J].
Xue, Luzheng ;
Salimi, Maryam ;
Panse, Isabel ;
Mjosberg, Jenny M. ;
McKenzie, Andrew N. J. ;
Spits, Hergen ;
Klenerman, Paul ;
Ogg, Graham .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (04) :1184-+