An Update on Clinical Trials: Is Tumor Angiogenesis Still a Viable Target in Advanced NSCLC?

被引:0
作者
Wakelee, Heather A. [1 ]
机构
[1] Stanford Univ, Med Oncol, Stanford, CA 94305 USA
关键词
CELL LUNG-CANCER; PHASE-III TRIAL; 1ST-LINE THERAPY; DOUBLE-BLIND; BEVACIZUMAB; PLACEBO; MULTICENTER; CISPLATIN;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MS03.04
引用
收藏
页码:S94 / S95
页数:2
相关论文
共 8 条
[1]   Randomized Phase III Trial of Maintenance Bevacizumab With or Without Pemetrexed After First-Line Induction With Bevacizumab, Cisplatin, and Pemetrexed in Advanced Nonsquamous Non-Small-Cell Lung Cancer: AVAPERL (MO22089) [J].
Barlesi, Fabrice ;
Scherpereel, Arnaud ;
Rittmeyer, Achim ;
Pazzola, Antonio ;
Tur, Neus Ferrer ;
Kim, Joo-Hang ;
Ahn, Myung-Ju ;
Aerts, Joachim G. J. V. ;
Gorbunova, Vera ;
Vikstrom, Anders ;
Wong, Elaine K. ;
Perez-Moreno, Pablo ;
Mitchell, Lada ;
Groen, Harry J. M. .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (24) :3004-+
[2]   Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial [J].
Garon, Edward B. ;
Ciuleanu, Tudor-Eliade ;
Arrieta, Oscar ;
Prabhash, Kumar ;
Syrigos, Konstantinos N. ;
Goksel, Tuncay ;
Park, Keunchil ;
Gorbunova, Vera ;
Dario Kowalyszyn, Ruben ;
Pikiel, Joanna ;
Czyzewicz, Grzegorz ;
Orlov, Sergey V. ;
Lewanski, Conrad R. ;
Thomas, Michael ;
Bidoli, Paolo ;
Dakhil, Shaker ;
Gans, Steven ;
Kim, Joo-Hang ;
Grigorescu, Alexandru ;
Karaseva, Nina ;
Reck, Martin ;
Cappuzzo, Federico ;
Alexandris, Ekaterine ;
Sashegyi, Andreas ;
Yurasov, Sergey ;
Perol, Maurice .
LANCET, 2014, 384 (9944) :665-673
[3]   Randomized Phase IIIb Trial Evaluating the Continuation of Bevacizumab Beyond Disease Progression in Patients with Advanced Non-Squamous Non-Small-Cell Lung Cancer after First-Line Treatment with Bevacizumab Plus Platinum-Based Chemotherapy: Treatment Rationale and Protocol Dynamics of the AvaALL (MO22097) Trial [J].
Gridelli, Cesare ;
Bennouna, Jaafar ;
de Castro, Javier ;
Dingemans, Anne-Marie C. ;
Griesinger, Frank ;
Grossi, Francesco ;
Rossi, Antonio ;
Thatcher, Nick ;
Wong, Elaine K. ;
Langer, Corey .
CLINICAL LUNG CANCER, 2011, 12 (06) :407-411
[4]   Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL) [J].
Reck, M. ;
von Pawel, J. ;
Zatloukal, P. ;
Ramlau, R. ;
Gorbounova, V. ;
Hirsh, V. ;
Leighl, N. ;
Mezger, J. ;
Archer, V. ;
Moore, N. ;
Manegold, C. .
ANNALS OF ONCOLOGY, 2010, 21 (09) :1804-1809
[5]   Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial [J].
Reck, Martin ;
Kaiser, Rolf ;
Mellemgaard, Anders ;
Douillard, Jean-Yves ;
Orlov, Sergey ;
Krzakowski, Maciej ;
von Pawel, Joachim ;
Gottfried, Maya ;
Bondarenko, Igor ;
Liao, Meilin ;
Gann, Claudia-Nanette ;
Barrueco, Jose ;
Gaschler-Markefski, Birgit ;
Novello, Silvia .
LANCET ONCOLOGY, 2014, 15 (02) :143-155
[6]   Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer [J].
Sandler, Alan ;
Gray, Robert ;
Perry, Michael C. ;
Brahmer, Julie ;
Schiller, Joan H. ;
Dowlati, Afshin ;
Lilenbaum, Rogerio ;
Johnson, David H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (24) :2542-2550
[7]   Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study [J].
Seto, Takashi ;
Kato, Terufumi ;
Nishio, Makoto ;
Goto, Koichi ;
Atagi, Shinji ;
Hosomi, Yukio ;
Yamamoto, Noboru ;
Hida, Toyoaki ;
Maemondo, Makoto ;
Nakagawa, Kazuhiko ;
Nagase, Seisuke ;
Okamoto, Isamu ;
Yamanaka, Takeharu ;
Tajima, Kosei ;
Harada, Ryosuke ;
Fukuoka, Masahiro ;
Yamamoto, Nobuyuki .
LANCET ONCOLOGY, 2014, 15 (11) :1236-1244
[8]   BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study of First-Line Carboplatin/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non-Small-Cell Lung Cancer [J].
Zhou, Caicun ;
Wu, Yi-Long ;
Chen, Gongyan ;
Liu, Xiaoqing ;
Zhu, Yunzhong ;
Lu, Shun ;
Feng, Jifeng ;
He, Jianxing ;
Han, Baohui ;
Wang, Jie ;
Jiang, Guoliang ;
Hu, Chunhong ;
Zhang, Hao ;
Cheng, Gang ;
Song, Xiangqun ;
Lu, You ;
Pan, Hongming ;
Zheng, Wenjuan ;
Yin, Anny-Yue .
JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (19) :2197-U108