The scent of Mycobacterium tuberculosis - Part II breath

被引：114

作者：

Syhre, Mona ^{[1
]}

Manning, Laurens ^{[2
,3
]}

Phuanukoonnon, Suparat ^{[2
]}

Harino, Paul ^{[2
]}

Chambers, Stephen T.

机构：

[1] Univ Otago, Dept Pathol, Christchurch Sch Med & Hlth Sci, Christchurch 8140, New Zealand

[2] Papua New Guinea Inst Med Res, Madang, Papua N Guinea

[3] Univ Western Australia, Perth, WA 6009, Australia

来源：

TUBERCULOSIS | 2009年 / 89卷 / 04期

关键词：

Breath; Methyl nicotinate; Mycobacterium tuberculosis; GC/MS-MS; SPME;

D O I：

10.1016/j.tube.2009.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro. We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：263 / 266

页数：4

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