Achieving Lower Insertion Loss and Higher Sensitivity in a SAW Biosensor via Optimization of Waveguide and Microcavity Structures

被引:18
作者
Li, Shuangming [1 ,2 ]
Sankaranarayanan, Subramanian K. R. S. [3 ]
Fan, Chunhai [4 ]
Su, Yan [4 ]
Bhethanabotla, Venkat R. [5 ]
机构
[1] Nanjing Univ Sci & Technol, Sch Mech Engn, Nanjing 210094, Peoples R China
[2] Univ S Florida, Dept Chem & Biomed Engn, Tampa, FL 33620 USA
[3] Ctr Nanoscale Mat, Argonne Natl Lab, Argonne, IL 60439 USA
[4] Nanjing Univ Sci & Technol, Sch Mech Engn, Nanjing 210094, Peoples R China
[5] Univ S Florida, Dept Chem Biomed Engn, Tampa, FL 33620 USA
基金
美国国家科学基金会;
关键词
Surface acoustic wave; biosensors; finite element modeling; waveguide; microcavities; CANCER-PATIENTS; OVARIAN-CANCER; SENSORS; ANGIOSTATIN; LITAO3;
D O I
10.1109/JSEN.2017.2651102
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Achieving low power consumption and high sensitivity is a major obstacle in realizing the potential of surface acoustic wave (SAW) devices in portable sensing applications. In this paper, we demonstrate that an optimal combination of a microcavity structure filled with a low acoustic impedance material in the delay path combined with a suitable wave guide lowers power consumption substantially and improves sensitivity. 3-D finite-element method (FEM) simulations were employed to systematically evaluate the effect of various filling and waveguide materials for similar to 100 MHz devices in ST quartz. Based on the simulated device designs, trends in device performance, and ease of fabrication, SAW sensors were fabricated in ST quartz with tantalum filling of the microcavity array along with an optimal SiO2 wave guide to achieve improvements on the order of 5 dB in insertion loss and nearly ten times the sensitivity compared with an SAW device without these modifications. This paper allows for the possibility of designing and realizing robust SAW sensors for detection at concentration levels of relevance to clinical diagnosis, i. e., sub-ng to ng/mL levels.
引用
收藏
页码:1608 / 1616
页数:9
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