Plant Viruses in Plant Molecular Pharming: Toward the Use of Enveloped Viruses

被引:30
作者
Ibrahim, Ahmad [1 ]
Odon, Valerie [1 ]
Kormelink, Richard [1 ]
机构
[1] Wageningen Univ & Res, Dept Plant Sci, Lab Virol, Wageningen, Netherlands
来源
FRONTIERS IN PLANT SCIENCE | 2019年 / 10卷
关键词
plant molecular pharming; non-enveloped viruses; plant rhabdoviruses; recombinant vaccines; virus like particles; biotechnology; TOBACCO-MOSAIC-VIRUS; VESICULAR-STOMATITIS-VIRUS; YELLOW-NET-VIRUS; LIQUID-CRYSTALLINE SUBSTANCES; MUCOSAL IMMUNE-RESPONSES; CHLOROTIC MOTTLE VIRUS; MODIFIED COAT PROTEIN; HIGH-LEVEL PRODUCTION; HIGH-YIELD PRODUCTION; HEPATITIS-B-VACCINE;
D O I
10.3389/fpls.2019.00803
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Plant molecular pharming has emerged as a reliable platform for recombinant protein expression providing a safe and low-cost alternative to bacterial and mammalian cells-based systems. Simultaneously, plant viruses have evolved from pathogens to molecular tools for recombinant protein expression, chimaeric viral vaccine production, and lately, as nanoagents for drug delivery. This review summarizes the genesis of viral vectors and agroinfection, the development of non-enveloped viruses for various biotechnological applications, and the on-going research on enveloped plant viruses.
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页数:18
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