Corneal changes in long-term chlorpromazine therapy

被引:0
|
作者
Kasetsuwan, Ngamjit [1 ]
Reinprayoon, Usanee [1 ]
Jariyakosol, Supharat [1 ]
机构
[1] Chulalongkorn Univ, Fac Med, Dept Ophthalmol, Bangkok 10330, Thailand
关键词
Confocal microscopy; Chlorpromazine; Pigment deposit;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective: To study ocular manifestations in patients who were on long-term use of chlorpromazine. Methods: A retrospective observational case study was made. Three patients, who were diagnosed as Schizophrenia and on long-term use of chlorpromazine for more than 20 years, were examined retrospectively. The examinations included clinical history, physical examination, slit-lamp biomicroscopy, and fundus examination. Confocal microstructure analyses of corneal changes were also performed on two cases. Results: A series of three cases, a 52-year-old woman, and two men of 45-year-old and 56-year-old, had a history of prolonged chlorpromazine use and presented with gradual onset of blurred vision in their both eyes for years. Slit-lamp biomicroscopy revealed multiple yellowish-white granular deposits on posterior stroma and corneal endothelium. Stellate yellowish-brown pigments deposited in the anterior subcapsular areas were also found. Fundus examination showed neither pigment epithelial mottling nor maculopathy. Confocal microscopic examination of two patients revealed numerous hyper-reflective deposits on the posterior stroma and corneal endothelium. There were no abnormalities in both endothelial cellular morphology and density. Conclusion: We reported ocular manifestations of three patients who were on long-term chlorpromazine therapy. Confocal imaging is useful for detection of abnormality in the corneal structure. Microstructure changes revealed numerous hyper-reflective deposits on the posterior stroma and endothelium without any changes in cellular morphology and density.
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页码:425 / 431
页数:7
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